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Substance Name: Pretomanid [USAN:INN]
RN: 187235-37-6
UNII: 2XOI31YC4N
InChIKey: ZLHZLMOSPGACSZ-NSHDSACASA-N
Note
- Nitroimidazopyran derived from 5-nitroimidazoles; a prodrug that requires activation by a bacterial F420-depedent glucose-6-phosphate dehydrogenase (Fgd) and nitroreductase to activate components that then inhibit bacterial mycolic acid and protein synthesis.
Molecular Formula
- C14-H12-F3-N3-O5
Molecular Weight
- 359.2588
Classification Code
- Antitubercular Agents
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Names and Synonyms
Name of Substance
- PA 824
- Pretomanid [USAN:INN]
Synonyms
- (S)-PA 824
- PA-824
- PA824
- Pretomanid
- UNII-2XOI31YC4N
Systematic Names
- 2-nitro-6-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo(2,1-b)(1,3)oxazine
- 5H-Imidazo(2,1-b)(1,3)oxazine, 6,7-dihydro-2-nitro-6-((4-(trifluoromethoxy)phenyl)methoxy)-, (6S)-
Registry Numbers
CAS Registry Number
- 187235-37-6
FDA UNII
- 2XOI31YC4N
System Generated Number
- 0187235376