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Substance Name: Pretomanid [USAN:INN]
RN: 187235-37-6
UNII: 2XOI31YC4N
InChIKey: ZLHZLMOSPGACSZ-NSHDSACASA-N

Note

  • Nitroimidazopyran derived from 5-nitroimidazoles; a prodrug that requires activation by a bacterial F420-depedent glucose-6-phosphate dehydrogenase (Fgd) and nitroreductase to activate components that then inhibit bacterial mycolic acid and protein synthesis.

Molecular Formula

  • C14-H12-F3-N3-O5

Molecular Weight

  • 359.2588
 

Classification Code

  • Antitubercular Agents
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Names and Synonyms

Name of Substance

  • PA 824
  • Pretomanid [USAN:INN]

Synonyms

  • (S)-PA 824
  • PA-824
  • PA824
  • Pretomanid
  • UNII-2XOI31YC4N

Systematic Names

  • 2-nitro-6-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo(2,1-b)(1,3)oxazine
  • 5H-Imidazo(2,1-b)(1,3)oxazine, 6,7-dihydro-2-nitro-6-((4-(trifluoromethoxy)phenyl)methoxy)-, (6S)-

Registry Numbers

CAS Registry Number

  • 187235-37-6

FDA UNII

  • 2XOI31YC4N

System Generated Number

  • 0187235376

Structure Descriptors

InChI

InChI=1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1

InChIKey

ZLHZLMOSPGACSZ-NSHDSACASA-N

Smiles

[O-][N+](=O)c1cn2C[C@@H](COc2n1)OCc3ccc(OC(F)(F)F)cc3