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Substance Name: dl-Methylephedrine hydrochloride [JAN]
RN: 18760-80-0
UNII: 99214P83XM
InChIKey: NTCYWJCEOILKNG-ROLPUNSJSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C11-H17-N-O.Cl-H

Molecular Weight

  • 215.7222
 
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Names and Synonyms

Name of Substance

  • dl-Methylephedrine hydrochloride [JAN]
  • Methylephedrine hydrochloride, dl-

Synonyms

  • DL-Methylephedrine hydrochloride
  • dl-N-Methylephedrine hydrochloride
  • EINECS 242-557-4
  • UNII-99214P83XM

Systematic Names

  • (R*,S*)-(1)-alpha-(1-(Dimethylamino)ethyl)benzyl alcohol hydrochloride
  • Benzenemethanol, alpha-(1-(dimethylamino)ethyl)-, hydrochloride, (R*,S*)-(+-)- (9CI)
  • Benzyl alcohol, alpha-(1-(dimethylamino)ethyl)-, hydrochloride, erythro- (+-)-

Registry Numbers

CAS Registry Number

  • 18760-80-0

FDA UNII

  • 99214P83XM

Other Registry Number

  • 942-46-1

System Generated Number

  • 0018760800

Molecular Formulas

Molecular Formula

  • C11-H17-N-O.Cl-H

Molecular Formula Fragments

  • C11-H17-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C11H17NO.ClH/c1-9(12(2)3)11(13)10-7-5-4-6-8-10;/h4-9,11,13H,1-3H3;1H/t9-,11-;/m0./s1

InChIKey

NTCYWJCEOILKNG-ROLPUNSJSA-N

Smiles

Cl.C[C@@H]([C@H](O)c1ccccc1)N(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 118mg/kg (118mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 60, Pg. 226, 1964.
guinea pig LD50 subcutaneous 358mg/kg (358mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 60, Pg. 226, 1964.
guinea pig LDLo intravenous 139mg/kg (139mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 125, Pg. 236, 1960.
mouse LD50 intraperitoneal 185mg/kg (185mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 209, 1962.
mouse LD50 intraperitoneal 220mg/kg (220mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 55, Pg. 653, 1959.
mouse LD50 intravenous 134mg/kg (134mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 60, Pg. 226, 1964.
mouse LD50 oral 758mg/kg (758mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 60, Pg. 226, 1964.
mouse LD50 subcutaneous 310mg/kg (310mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 55, Pg. 653, 1959.
mouse LD50 subcutaneous 699mg/kg (699mg/kg)   Drugs in Japan Vol. 6, Pg. 827, 1982.
rabbit LDLo intravenous 55mg/kg (55mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 36, Pg. 363, 1929.
rat LD50 intraperitoneal 200mg/kg (200mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 1705, 1982.