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Substance Name: Tetrahydrouridine
RN: 18771-50-1
UNII: 0NIZ8H6OL8
InChIKey: UCKYOOZPSJFJIZ-XVKVHKPRSA-N

Note

  • An inhibitor of nucleotide metabolism.

Molecular Formula

  • C9-H16-N2-O6

Molecular Weight

  • 248.2334
 

Classification Codes

  • Antimetabolites
  • Drug / Therapeutic Agent
  • Noxae
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Names and Synonyms

Name of Substance

  • Tetrahydrouridine

MeSH Heading

  • Tetrahydrouridine

Synonyms

  • 2(1H)-Pyrimidinone, tetrahydro-4-hydroxy-1-beta-D-ribofuranosyl-
  • 3,4,5,6-Tetrahydrouridine
  • 5,6-Dihydrouridine
  • BRN 0752319
  • NSC 112907
  • NSC-112907
  • NSC-112907-D
  • Tetrahydrouridine
  • U 23284
  • UNII-0NIZ8H6OL8

Systematic Name

  • 2(1H)-Pyrimidinone, tetrahydro-4-hydroxy-1-beta-D-ribofuranosyl-

Registry Numbers

CAS Registry Number

  • 18771-50-1

FDA UNII

  • 0NIZ8H6OL8

Other Registry Number

  • 68060-67-3

System Generated Number

  • 0018771501

Structure Descriptors

InChI

1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1

InChIKey

UCKYOOZPSJFJIZ-XVKVHKPRSA-N

Smiles

C1CN(C(=O)NC1O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 1gm/kg (1000mg/kg)   National Technical Information Service. Vol. PB211-590,
dog LD unreported > 1gm/kg (1000mg/kg)   Pharmaceutical Chemistry Journal Vol. 10, Pg. 423, 1976.
monkey LD unreported > 1gm/kg (1000mg/kg)   Pharmaceutical Chemistry Journal Vol. 10, Pg. 423, 1976.