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Substance Name: 3-Hydroxyprazepam
RN: 18818-61-6
InChIKey: SYUMLTUHTWFDGE-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C19-H17-Cl-N2-O2

Molecular Weight

  • 340.8083
 
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Names and Synonyms

Results Name

  • 3-Hydroxyprazepam

Synonyms

  • 1,3-Dihydro-7-chloro-1-(cyclopropylmethyl)-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one
  • 3-Hydroxyprazepam
  • 5-25-02-00245 (Beilstein Handbook Reference)
  • BRN 0763564

Systematic Name

  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(cyclopropylmethyl)-3-hydroxy-5-phenyl-

Registry Numbers

CAS Registry Number

  • 18818-61-6

System Generated Number

  • 0018818616

Structure Descriptors

InChI

1S/C19H17ClN2O2/c20-14-8-9-16-15(10-14)17(13-4-2-1-3-5-13)21-18(23)19(24)22(16)11-12-6-7-12/h1-5,8-10,12,18,23H,6-7,11H2

InChIKey

SYUMLTUHTWFDGE-UHFFFAOYSA-N

Smiles

OC1N=C(c2ccccc2)c3cc(Cl)ccc3N(CC4CC4)C1=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral > 4gm/kg (4000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
mouse LDLo intraperitoneal 2gm/kg (2000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
mouse LDLo intraperitoneal 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
mouse LDLo subcutaneous 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
rat LD50 intraperitoneal > 2gm/kg (2000mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
rat LD50 oral > 4gm/kg (4000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
rat LD50 oral > 4gm/kg (4000mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 241, 1978.