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Substance Name: Pyricarbate [INN]
RN: 1882-26-4
UNII: 81R511UV73
InChIKey: YEKQSSHBERGOJK-UHFFFAOYSA-N

Note

  • A drug that has been given by mouth in the treatment of atherosclerosis and other vascular disorders, hyperlipidemias, and thrombo-embolic disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1408)

Molecular Formula

  • C11-H15-N3-O4

Molecular Weight

  • 253.257
 

Classification Codes

  • Antimetabolites
  • Drug / Therapeutic Agent
  • Hypolipidemic Agents
  • Lipid Regulating Agents
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Names and Synonyms

Name of Substance

  • Pyricarbate [INN]
  • Pyridinol carbamate
  • Pyridinolcarbamate

MeSH Heading

  • Pyridinolcarbamate

Synonyms

  • 5-21-04-00441 (Beilstein Handbook Reference)
  • Anginin
  • Anginine
  • Angioxine
  • Aterosan
  • Atover
  • BRN 1544252
  • Cicloven
  • Colesterinex
  • Duvaline
  • EINECS 217-538-9
  • H-3749
  • Methylcarbamic acid 2,6-pyridinediyldimethylene ester
  • Movecil
  • Parmidine
  • Parmidine R
  • Piridinol carbamato
  • Piridinol carbamato [Spanish]
  • Prodectin
  • Pyricarbate
  • Pyricarbato
  • Pyricarbato [INN-Spanish]
  • Pyricarbatum
  • Pyricarbatum [INN-Latin]
  • Pyridinol carbamate
  • Ravenil
  • Sospitan 500
  • UNII-81R511UV73
  • Vasagin
  • Vasapril
  • Vasocil
  • Vasoverin
  • Veranterol

Systematic Names

  • 2,6-Pyridinedimethanol, bis(methylcarbamate) (ester)
  • 2,6-Pyridinediyldimethylene bis(methylcarbamate)
  • Carbamic acid, methyl-, 2,6-pyridinediyldimethylene ester
  • Pyricarbate

Registry Numbers

CAS Registry Number

  • 1882-26-4

FDA UNII

  • 81R511UV73

Other Registry Number

  • 51527-88-9

System Generated Number

  • 0001882264

Structure Descriptors

InChI

1S/C11H15N3O4/c1-12-10(15)17-6-8-4-3-5-9(14-8)7-18-11(16)13-2/h3-5H,6-7H2,1-2H3,(H,12,15)(H,13,16)

InChIKey

YEKQSSHBERGOJK-UHFFFAOYSA-N

Smiles

c1(nc(COC(NC)=O)ccc1)COC(NC)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 1gm/kg (1000mg/kg)   American Heart Journal. Vol. 71, Pg. 297, 1966.
mouse LD50 intraperitoneal 1450mg/kg (1450mg/kg)   Drugs in Japan Vol. -, Pg. 894, 1990.
mouse LD50 oral 3100mg/kg (3100mg/kg)   Pharmaceutical Chemistry Journal Vol. 11, Pg. 1573, 1977.
mouse LD50 subcutaneous 5700mg/kg (5700mg/kg)   Drugs in Japan Vol. -, Pg. 894, 1990.
rabbit LD50 intraperitoneal 1480mg/kg (1480mg/kg)   Drugs in Japan Vol. -, Pg. 894, 1990.
rabbit LD50 oral 4250mg/kg (4250mg/kg)   Drugs in Japan Vol. 6, Pg. 642, 1982.
rabbit LD50 subcutaneous 5200mg/kg (5200mg/kg)   Drugs in Japan Vol. -, Pg. 894, 1990.
rat LD50 intraperitoneal 1260mg/kg (1260mg/kg)   Drugs in Japan Vol. -, Pg. 894, 1990.
rat LD50 oral 1230mg/kg (1230mg/kg)   Archivos de Farmacologia y Toxicologia. Vol. 6, Pg. 255, 1980.
rat LD50 subcutaneous 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 894, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 136-137 deg C   EXP
log P (octanol-water) 0.24 (none)   EXP
Water Solubility 1.38E+04 mg/L 25 EST
Vapor Pressure 4.35E-05 mm Hg 25 EST
Henry's Law Constant 1.89E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.87E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.