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Substance Name: Norfenfluramine
RN: 1886-26-6
UNII: 037A9J3PSW
InChIKey: MLBHFBKZUPLWBD-UHFFFAOYSA-N

Note

  • A FENFLURAMINE analog that inhibits serotonin uptake and may provoke release of serotonin. It is used as an appetite depressant and an experimental tool in animal studies.

Molecular Formula

  • C10-H12-F3-N

Molecular Weight

  • 203.2058
 

Classification Codes

  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Neurotransmitter Agents
  • Neurotransmitter Uptake Inhibitors
  • Serotonin Agents
  • Serotonin Uptake Inhibitors
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Names and Synonyms

Name of Substance

  • Norfenfluramine

MeSH Heading

  • Norfenfluramine

Synonyms

  • 1-(3-(Trifluoromethyl)phenyl)-2-propanamine
  • 1-(3-Trifluoromethylphenyl)-2-amino propane
  • 1-(m-Trifluoromethylphenyl)-2-aminopropane
  • 1-Methyl-2-(m-trifluoromethylphenyl)ethylamine
  • alpha-Methyl-3-trifluoromethylphenethylamine
  • alpha-Methyl-m-trifluoromethylphenethylamine
  • BRN 0392132
  • Desethylfenfluramine
  • JP 92
  • Norfenfloramine
  • Norfenfluramine
  • NSC 43036
  • Phenethylamine, alpha-methyl-m-trifluoromethyl-
  • UNII-037A9J3PSW

Systematic Names

  • Benzeneethanamine, alpha-methyl-3-(trifluoromethyl)- (9CI)
  • Phenethylamine, alpha-methyl-m-trifluoromethyl-

Registry Numbers

CAS Registry Number

  • 1886-26-6

FDA UNII

  • 037A9J3PSW

System Generated Number

  • 0001886266

Structure Descriptors

InChI

1S/C10H12F3N/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13/h2-4,6-7H,5,14H2,1H3

InChIKey

MLBHFBKZUPLWBD-UHFFFAOYSA-N

Smiles

CC(N)Cc1cccc(c1)C(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 51mg/kg (51mg/kg)   "International Symposium on Amphetamines and Related Compounds, Proceedings, Mario Negri Institute for Pharmacological Research, Milan, 1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970Vol. -, Pg. 21, 1970.