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Substance Name: Pipamperone [USAN:INN:BAN]
RN: 1893-33-0
UNII: 5402501F0W
InChIKey: AXKPFOAXAHJUAG-UHFFFAOYSA-N

Molecular Formula

  • C21-H30-F-N3-O2

Molecular Weight

  • 375.485
 

Classification Codes

  • Antipsychotic
  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Serotonin Agents
  • Serotonin Antagonists
  • Tranquilizing Agents
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Names and Synonyms

Name of Substance

  • Pipamperone
  • Pipamperone [USAN:INN:BAN]

Synonyms

  • (1,4'-Bipiperidine)-4'-carboxamide, 1'-(4-(4-fluorophenyl)-4-oxobutyl)-
  • 1'-(3-(p-Fluorobenzoyl)propyl)-(1,4'-bipiperidine)-4'-carboxamide
  • 4'-Fluoro-4-(4-N-piperidino-4-carbamidopiperidino)butyrophenone
  • 5-22-13-00536 (Beilstein Handbook Reference)
  • BRN 0496532
  • CCRIS 9071
  • Dipiperal
  • Dipiperon
  • Dipiperone
  • Floropipamide
  • Isonipacotamide, 1-(3-(p-fluorobenzoyl)propyl)-4-piperidino-
  • McN-JR-3345
  • p-Fluoro-gamma-(4-piperidino-4-carbamoylpiperidino)butyrophenone
  • Pipamperona
  • Pipamperona [INN-Spanish]
  • Pipamperone
  • Pipamperonum
  • Pipamperonum [INN-Latin]
  • Piperonil
  • Piperonyl
  • R 3345
  • UNII-5402501F0W

Systematic Names

  • (1,4'-Bipiperidine)-4'-carboxamide, 1'-(3-(p-fluorobenzoyl)propyl)-
  • (1,4'-Bipiperidine)-4'-carboxamide, 1'-(4-(4-fluorophenyl)-4-oxobutyl)-
  • 1,4'-Bipiperidine)-4'-carboxamide, 1'-(4-(4-fluorophenyl)-4-oxobutyl)-

Registry Numbers

CAS Registry Number

  • 1893-33-0

FDA UNII

  • 5402501F0W

Related Registry Number

  • 2448-68-2 (di-hydrochloride)

System Generated Number

  • 0001893330

Structure Descriptors

InChI

1S/C21H30FN3O2/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25/h6-9H,1-5,10-16H2,(H2,23,27)

InChIKey

AXKPFOAXAHJUAG-UHFFFAOYSA-N

Smiles

C1(N2CCCCC2)(CCN(CCCC(c2ccc(F)cc2)=O)CC1)C(N)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 subcutaneous > 10mg/kg (10mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
dog LD50 subcutaneous > 40mg/kg (40mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
monkey LD50 subcutaneous > 20mg/kg (20mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse LD50 intravenous 66mg/kg (66mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 188, 1972.
mouse LD50 oral 490mg/kg (490mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 15, Pg. 485, 1977.
mouse LD50 subcutaneous 160mg/kg (160mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 188, 1972.
rat LD50 intravenous 48mg/kg (48mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 188, 1972.
rat LD50 oral 160mg/kg (160mg/kg)   Acta Neurologia et Psychiatrica Belgica. Vol. 61, Pg. 611, 1961.
rat LD50 subcutaneous 160mg/kg (160mg/kg)   Acta Neurologia et Psychiatrica Belgica. Vol. 61, Pg. 611, 1961.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.02 (none)   EXP
Water Solubility 81.7 mg/L 25 EST
Vapor Pressure 9.48E-11 mm Hg 25 EST
Henry's Law Constant 1.60E-17 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.08E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.