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Substance Name: Oblimersen sodium [USAN]
RN: 190977-41-4
UNII: 85J5ZP6YSL
InChIKey: IBXPAFBDJCXCDW-MHFPCNPESA-A

Note

  • Targets the Bcl-2 oncogene good efficacy with low toxicity tumour regressions.

Classification Code

  • Treatment of Cancer and Rheumatological Diseases (an Antisense Oligonucleotide)

Molecular Formula

  • C172-H204-N62-Na17-O91-P17-S17

Molecular Weight

  • 6058.3566
 
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Names and Synonyms

Name of Substance

  • Oblimersen sodium [USAN]

Synonyms

  • Augmerosen
  • D-G3139
  • DNA, d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T)
  • G 3139
  • G3139
  • Genasense
  • Oblimersen
  • Oblimersen sodium
  • UNII-85J5ZP6YSL

Systematic Names

  • DNA, d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T)
  • P-Thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioadenylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioadenylyl-(3'to 5')-thymidine heptadecasodium salt

Registry Numbers

CAS Registry Number

  • 190977-41-4

FDA UNII

  • 85J5ZP6YSL

System Generated Number

  • 0190977414

Structure Descriptors

InChI

1S/C172H221N62O91P17S17.17Na/c1-69-39-225(169(253)213-149(69)237)117-21-73(236)92(292-117)44-274-326(257,343)320-85-33-129(229-63-191-135-141(181)187-61-189-143(135)229)303-103(85)55-285-332(263,349)314-79-27-122(221-17-9-113(177)201-165(221)249)295-95(79)47-278-330(261,347)312-78-26-121(220-16-8-112(176)200-164(220)248)298-98(78)50-280-338(269,355)322-87-35-131(231-65-193-137-145(231)205-157(183)209-153(137)241)305-105(87)57-287-334(265,351)316-81-29-124(223-19-11-115(179)203-167(223)251)299-99(81)51-281-339(270,356)323-88-36-132(232-66-194-138-146(232)206-158(184)210-154(138)242)307-107(88)59-289-337(268,354)319-84-32-128(228-42-72(4)152(240)216-172(228)256)302-102(84)54-284-341(272,358)325-90-38-134(234-68-196-140-148(234)208-160(186)212-156(140)244)306-106(90)58-288-335(266,352)317-82-30-125(224-20-12-116(180)204-168(224)252)300-100(82)52-282-340(271,357)324-89-37-133(233-67-195-139-147(233)207-159(185)211-155(139)243)308-108(89)60-290-342(273,359)321-86-34-130(230-64-192-136-142(182)188-62-190-144(136)230)304-104(86)56-286-333(264,350)315-80-28-123(222-18-10-114(178)202-166(222)250)296-96(80)48-277-328(259,345)310-76-24-119(218-14-6-110(174)198-162(218)246)294-94(76)46-276-329(260,346)311-77-25-120(219-15-7-111(175)199-163(219)247)297-97(77)49-279-336(267,353)318-83-31-127(227-41-71(3)151(239)215-171(227)255)301-101(83)53-283-331(262,348)313-75-23-118(217-13-5-109(173)197-161(217)245)293-93(75)45-275-327(258,344)309-74-22-126(291-91(74)43-235)226-40-70(2)150(238)214-170(226)254;;;;;;;;;;;;;;;;;/h5-20,39-42,61-68,73-108,117-134,235-236H,21-38,43-60H2,1-4H3,(H,257,343)(H,258,344)(H,259,345)(H,260,346)(H,261,347)(H,262,348)(H,263,349)(H,264,350)(H,265,351)(H,266,352)(H,267,353)(H,268,354)(H,269,355)(H,270,356)(H,271,357)(H,272,358)(H,273,359)(H2,173,197,245)(H2,174,198,246)(H2,175,199,247)(H2,176,200,248)(H2,177,201,249)(H2,178,202,250)(H2,179,203,251)(H2,180,204,252)(H2,181,187,189)(H2,182,188,190)(H,213,237,253)(H,214,238,254)(H,215,239,255)(H,216,240,256)(H3,183,205,209,241)(H3,184,206,210,242)(H3,185,207,211,243)(H3,186,208,212,244);;;;;;;;;;;;;;;;;/q;17*+1/p-17/t73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91+,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,117+,118+,119+,120+,121+,122+,123+,124+,125+,126+,127+,128+,129+,130+,131+,132+,133+,134+,326?,327?,328?,329?,330?,331?,332?,333?,334?,335?,336?,337?,338?,339?,340?,341?,342?;;;;;;;;;;;;;;;;;/m0................./s1

InChIKey

IBXPAFBDJCXCDW-MHFPCNPESA-A

Smiles

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CC1=CN([C@H]2C[C@H](O)[C@@H](COP(=O)([S-])O[C@H]3C[C@@H](O[C@@H]3COP(=O)([S-])O[C@H]4C[C@@H](O[C@@H]4COP(=O)([S-])O[C@H]5C[C@@H](O[C@@H]5COP(=O)([S-])O[C@H]6C[C@@H](O[C@@H]6COP(=O)([S-])O[C@H]7C[C@@H](O[C@@H]7COP(=O)([S-])O[C@H]8C[C@@H](O[C@@H]8COP(=O)([S-])O[C@H]9C[C@@H](O[C@@H]9COP(=O)([S-])O[C@H]%10C[C@@H](O[C@@H]%10COP(=O)([S-])O[C@H]%11C[C@@H](O[C@@H]%11COP(=O)([S-])O[C@H]%12C[C@@H](O[C@@H]%12COP(=O)([S-])O[C@H]%13C[C@@H](O[C@@H]%13COP(=O)([S-])O[C@H]%14C[C@@H](O[C@@H]%14COP(=O)([S-])O[C@H]%15C[C@@H](O[C@@H]%15COP(=O)([S-])O[C@H]%16C[C@@H](O[C@@H]%16COP(=O)([S-])O[C@H]%17C[C@@H](O[C@@H]%17COP(=O)([S-])O[C@H]%18C[C@@H](O[C@@H]%18COP(=O)([S-])O[C@H]%19C[C@@H](O[C@@H]%19CO)N%20C=C(C)C(=O)NC%20=O)N%21C=CC(=NC%21=O)N)N%22C=C(C)C(=O)NC%22=O)N%23C=CC(=NC%23=O)N)N%24C=CC(=NC%24=O)N)N%25C=CC(=NC%25=O)N)n%26cnc%27c(N)ncnc%26%27)n%28cnc%29C(=O)NC(=Nc%28%29)N)N%30C=CC(=NC%30=O)N)n%31cnc%32C(=O)NC(=Nc%31%32)N)N%33C=C(C)C(=O)NC%33=O)n%34cnc%35C(=O)NC(=Nc%34%35)N)N%36C=CC(=NC%36=O)N)n%37cnc%38C(=O)NC(=Nc%37%38)N)N%39C=CC(=NC%39=O)N)N%40C=CC(=NC%40=O)N)n%41cnc%42c(N)ncnc%41%42)O2)C(=O)NC1=O