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Substance Name: Methisazone [USAN]
RN: 1910-68-5
UNII: K3QML4J07E
InChIKey: DLGSOJOOYHWROO-WQLSENKSSA-N

Note

  • An antiviral agent effective against pox viruses.

Molecular Formula

  • C10-H10-N4-O-S

Molecular Weight

  • 234.282
 

Classification Codes

  • Anti-Infective Agents
  • Antiviral
  • Antiviral Agents
  • Drug / Therapeutic Agent
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Methisazone
  • Methisazone [USAN]
  • Metisazone [INN]

MeSH Heading

  • Methisazone

Synonyms

  • 1-Methylindole-2,3-dione 3-(thiosemicarbazone)
  • 1-Methylisatin 3-thiosemicarbazone
  • 1-Methylisatin beta-thiosemicarbazone
  • 33T57
  • AI3-62297
  • B. W. 33-T-57
  • beta-Thiosemicarbazone-N-methylisatin
  • BW 33-T-57
  • Compound 33T57
  • EINECS 217-616-2
  • Isatin, 1-methyl-, 3-(thiosemicarbazone)
  • Kemoviran
  • Marboran
  • Methisazone
  • Metisazon
  • Metisazona
  • Metisazona [INN-Spanish]
  • Metisazone
  • Metisazonum
  • Metisazonum [INN-Latin]
  • N-Methylindole-2,3-dione thiosemicarbazone
  • N-Methylisatin 3-(thiosemicarbazone)
  • N-Methylisatin beta-thiosemicarbazide
  • N-Methylisatin thiosemicarbazone
  • N-Methylisatin-beta-thiosemicarbazone
  • NSC 69811
  • NSC 70969
  • NSC-69811
  • UNII-K3QML4J07E
  • Viruzona

Systematic Names

  • Hydrazinecarbothioamide, 2-(1,2-dihydro-1-methyl-2-oxo-3H-indol-3-ylidene)-
  • Indole-2,3-dione, 1-methyl-, 3-(thiosemicarbazone)
  • Metisazone

Registry Numbers

CAS Registry Number

  • 1910-68-5

FDA UNII

  • K3QML4J07E

System Generated Number

  • 0001910685

Structure Descriptors

InChI

1S/C10H10N4OS/c1-14-7-5-3-2-4-6(7)8(9(14)15)12-13-10(11)16/h2-5H,1H3,(H3,11,13,16)/b12-8-

InChIKey

DLGSOJOOYHWROO-WQLSENKSSA-N

Smiles

c12\C(C(=O)N(c2cccc1)C)=N\NC(N)=S

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 56mg/kg (56mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02255,
mouse LD50 oral 4gm/kg (4000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1704, 1972.
mouse LD50 subcutaneous > 50gm/kg (50000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1704, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 245 deg C   EXP
log P (octanol-water) 0.980 (none)   EST
Atmospheric OH Rate Constant 9.95E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.