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Substance Name: Pramipexole dihydrochloride [USAN:USP]
RN: 191217-81-9
UNII: 3D867NP06J
InChIKey: APVQOOKHDZVJEX-QTPLPEIMSA-N

Classification Codes

  • Antidepressant
  • Antiparkinsonian
  • Antischizophrenic
  • Dopamine Agonist

Molecular Formula

  • C10-H17-N3-S.2Cl-H.H2-O

Molecular Weight

  • 302.2679
 
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Names and Synonyms

Name of Substance

  • Pramipexole dihydrochloride [USAN:USP]

Synonyms

  • (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride monohydrate
  • BI-sifrol
  • Mirapex
  • PNU 98528E
  • PNU-98528E
  • Pramipexole dihydrochloride monohydrate
  • Pramipexole HCl hydrate
  • SND919CL2Y
  • UNII-3D867NP06J

Systematic Name

  • 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, monohydrate, (6S)-

Registry Numbers

CAS Registry Number

  • 191217-81-9

FDA UNII

  • 3D867NP06J

System Generated Number

  • 0191217819

Structure Descriptors

InChI

1S/C10H17N3S.2ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H;1H2/t7-;;;/m0.../s1

InChIKey

APVQOOKHDZVJEX-QTPLPEIMSA-N

Smiles

O.Cl.Cl.CCCN[C@H]1CCc2nc(N)sc2C1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 91ug/kg (0.091mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 891, 1999.
mouse LDLo oral 1700mg/kg (1700mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 891, 1999.
rat LD50 oral > 800mg/kg (800mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 891, 1999.