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Substance Name: Duvoglustat [USAN:INN]
RN: 19130-96-2
UNII: FZ56898FLE
InChIKey: LXBIFEVIBLOUGU-JGWLITMVSA-N

Note

  • An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity.

Molecular Formula

  • C6-H13-N-O4

Molecular Weight

  • 163.1717
 

Classification Codes

  • Anti-Infective Agents
  • Antiviral Agents
  • Enzyme Inhibitors
  • Treatment of Pompe Disease
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Names and Synonyms

Name of Substance

  • 1-Deoxynojirimycin
  • Duvoglustat [USAN:INN]

MeSH Heading

  • 1-Deoxynojirimycin

Synonyms

  • 1,5-Deoxy-1,5-imino-D-mannitol
  • 1-Deoxymannojirimycin
  • 1-Deoxynojirimycin
  • BAY-h 5595
  • Duvoglustat
  • EC 606-239-2
  • Moranoline
  • UNII-FZ56898FLE

Systematic Names

  • (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol
  • 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R-(2alpha,3beta,4alpha,5beta))-

Registry Numbers

CAS Registry Number

  • 19130-96-2

FDA UNII

  • FZ56898FLE

Other Registry Number

  • 70956-02-4

System Generated Number

  • 0019130962

Structure Descriptors

InChI

1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1

InChIKey

LXBIFEVIBLOUGU-JGWLITMVSA-N

Smiles

C1[C@@H]([C@H]([C@@H]([C@H](N1)CO)O)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral > 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
International Journal of Toxicology. Vol. 16(Suppl,

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -1.80E+00 (none)   EXP
Water Solubility 1.00E+06 mg/L 25 EST
Vapor Pressure 5.38E-08 mm Hg 25 EST
Henry's Law Constant 4.07E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.36E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.