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Substance Name: Lenalidomide [USAN:INN:BAN]
RN: 191732-72-6
UNII: F0P408N6V4
InChIKey: GOTYRUGSSMKFNF-UHFFFAOYSA-N

Notes

  • An immunomodulator.
  • An immunomodulator

    NCI: A thalidomide analog with potential antineoplastic activity. Lenalidomide inhibits TNF-alpha production, stimulates T cells, reduces serum levels of the cytokines vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and inhibits angiogenesis. This agent also promotes G1 cell cycle arrest and apoptosis of malignant cells. (NCI Thesaurus)

Molecular Formula

  • C13-H13-N3-O3

Molecular Weight

  • 259.2637
 

Classification Codes

  • Angiogenesis Inhibitors
  • Angiogenesis Modulating Agents
  • Antineoplastic Agents
  • Growth Inhibitors
  • Growth Substances
  • Immunologic Factors
  • Immunomulator Intended for use in the Treatment of Multiple Myeloma, Myelodysplastic Syndromes, Solid Tumors Including Glioma and Metastatic Melanoma, Crohn's Disease, and Heart Failure

Names and Synonyms

Name of Substance

  • Lenalidomide
  • Lenalidomide [USAN:INN:BAN]

Synonyms

  • 2,6-Piperidinedione, 3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
  • 3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
  • 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
  • CC 5013
  • CC-5013
  • CDC 501
  • CDC-501
  • ENMD 0997
  • HSDB 8220
  • Lenalidomide
  • Revimid
  • Revlimid
  • UNII-F0P408N6V4

Systematic Name

  • 2,6-Piperidinedione, 3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-

Registry Numbers

CAS Registry Number

  • 191732-72-6

FDA UNII

  • F0P408N6V4

Other Registry Numbers

  • 346670-73-3
  • 443912-14-9

System Generated Number

  • 0191732726

Structure Descriptors

InChI

1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)

InChIKey

GOTYRUGSSMKFNF-UHFFFAOYSA-N

Smiles

c1cc2c(c(c1)N)CN(C2=O)C3CCC(=O)NC3=O