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Substance Name: Prazosin [INN:BAN]
RN: 19216-56-9
UNII: XM03YJ541D
InChIKey: IENZQIKPVFGBNW-UHFFFAOYSA-N
Note
- A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
Molecular Formula
- C19-H21-N5-O4
Molecular Weight
- 383.4059
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenergic Agents
- Adrenergic alpha-1 Receptor Antagonists
- Adrenergic alpha-Antagonists
- Adrenergic Antagonists
- Antihypertensive Agents
- Antiviral (COVID-19)
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Human Data
- Neurotransmitter Agents
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Prazosin
- Prazosin [INN:BAN]
MeSH Heading
- Prazosin
Synonyms
- 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine
- 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline
- 5-25-13-00365 (Beilstein Handbook Reference)
- BRN 0768345
- EINECS 242-885-8
- Furazosin
- Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-
- Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-
- Prazosin
- Prazosina
- Prazosina [INN-Spanish]
- Prazosine
- Prazosine [INN-French]
- Prazosinum
- Prazosinum [INN-Latin]
- Quinazoline, 4-amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)-
- UNII-XM03YJ541D
Systematic Names
- Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-
- Prazosin
- Quinazoline, 4-amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)-
Registry Numbers
CAS Registry Number
- 19216-56-9
FDA UNII
- XM03YJ541D
System Generated Number
- 0019216569
Structure Descriptors
InChI
InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)InChIKey
IENZQIKPVFGBNW-UHFFFAOYSA-NSmiles
COc1cc2nc(nc(N)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
human | TDLo | oral | 280ug/kg (0.28mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | British Medical Journal. Vol. 2, Pg. 508, 1976. |
human | TDLo | oral | 1260ug/kg (1.26mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) KIDNEY, URETER, AND BLADDER: OTHER CHANGES | British Medical Journal. Vol. 1, Pg. 622, 1978. |
man | TDLo | oral | 1143ug/kg (1.143mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Acta Medica Scandinavica. Vol. 213, Pg. 157, 1983. |
mouse | LD50 | intravenous | > 400mg/kg (400mg/kg) | Russian Pharmacology and Toxicology Vol. 50, Pg. 182, 1987. | |
mouse | LD50 | oral | > 4gm/kg (4000mg/kg) | Bollettino Chimico Farmaceutico. Vol. 128, Pg. 129, 1989. | |
rat | LD | oral | > 3gm/kg (3000mg/kg) | United States Patent Document. Vol. #4734418, | |
women | TDLo | oral | 20ug/kg (0.02mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Annals of Internal Medicine. Vol. 97, Pg. 455, 1982. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 279 | deg C | EXP | |
log P (octanol-water) | 1.280 | (none) | EST | |
Atmospheric OH Rate Constant | 2.84E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.