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Substance Name: Tipifarnib [USAN:INN]
RN: 192185-72-1
UNII: MAT637500A
InChIKey: PLHJCIYEEKOWNM-HHHXNRCGSA-N

Notes

  • Farnesyltranstransferase inhibitor.
  • Farnesyltranstransferase inhibitor.

    NCI: A nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis. (NCI Thesaurus)

Molecular Formula

  • C27-H22-Cl2-N4-O

Molecular Weight

  • 489.4038
 

Classification Codes

  • Antineoplastic Agents
  • Treatment of Advanced Pancreatic Cancer, Colorectal Cancer, and Non-Small Cell Lung Cancer
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Names and Synonyms

Name of Substance

  • Tipifarnib
  • Tipifarnib [USAN:INN]

Synonyms

  • (R)-( )-R115777
  • (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
  • 2 (1H))-Quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-, (+)-
  • CCRIS 9329
  • Tipifarnib
  • UNII-MAT637500A
  • Zarnestra

Systematic Names

  • (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
  • 2 (1H))-Quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-

Registry Numbers

CAS Registry Number

  • 192185-72-1

FDA UNII

  • MAT637500A

System Generated Number

  • 0192185721

Structure Descriptors

InChI

1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1

InChIKey

PLHJCIYEEKOWNM-HHHXNRCGSA-N

Smiles

Cn1cncc1[C@@](c2ccc(cc2)Cl)(c3ccc4c(c3)c(cc(=O)n4C)c5cccc(c5)Cl)N