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Substance Name: Tositumomab I-131
RN: 192391-48-3
UNII: K1KT5M40JC

Notes

  • Iodine-131-labeled anti-CD20 antibody for radioimmunotherapy of B-cell non-Hodgkin's lymphoma.
  • NCI: A murine IgG2a lambda monoclonal antibody, both unradiolabeled and radiolabeled with iodine I 131, directed against the human B cell-specific surface antigen CD20. Tositumomab binds to CD20, resulting in complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), and apoptosis in B cells expressing CD20; in addition to the antibody-mediated cytotoxicity, iodine I 131 tositumomab delivers cytotoxic ionizing radiation specifically to CD20-expressing B cells. In a two-step therapeutic regimen, a predose of unradiolabeled tositumomab is administered first followed by the administration of a dosimetric dose of iodine I 131 tositumomab; 7-14 days later, a therapeutic dose of iodine I 131 tositumomab is administered. The predose of unradiolabeled tositumomab binds to nontumor B cells, increasing the terminal half-life of radiolabeled antibody while protecting nontumor B cells from radiolabeled antibody-mediated radiocytotoxicity. (NCI Thesaurus)

Molecular Formula

  • Unspecified

Molecular Weight

  • 131.0
 

Classification Code

  • Antineoplastic Agents

Names and Synonyms

Name of Substance

  • Tositumomab I-131

Synonyms

  • 131Iodine-Anti-B1
  • Bexxar
  • Bexxar therapeutic regimen
  • I-131 Tositumomab therapeutic regimen
  • Immunoglobulin G2a anti-(human antigen CD 20) (mouse monoclonal clone B1R1 gamma2a-chain), disulfide with mouse monoclonal clone B1R1 lambdax-chain, dimer, Iodine-131I-labeled
  • Iodine-131 Anti-B1 Antibody
  • Iodine-131 Tositumomab
  • Tositumomab / iodine I 131
  • Tositumomab and iodine I 131 tositumomab
  • Tositumomab I 131
  • Tositumomab I-131
  • UNII-K1KT5M40JC

Systematic Name

  • Immunoglobulin G2a, anti-(human CD20 (antigen)) (mouse monoclonal clone B1R1 gamma2a-chain), disulfide with mouse monoclonal clone B1R1 lambdax-chain, dimer, iodine-131I salt

Registry Numbers

CAS Registry Number

  • 192391-48-3

FDA UNII

  • K1KT5M40JC

System Generated Number

  • 0192391483