Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Lopinavir [USAN:USP:INN:BAN]
RN: 192725-17-0
UNII: 2494G1JF75
InChIKey: KJHKTHWMRKYKJE-SUGCFTRWSA-N

Note

  • An HIV protease inhibitor used in a fixed-dose combination with RITONAVIR. It is also an inhibitor of CYTOCHROME P-450 CYP3A.

Molecular Formula

  • C37-H48-N4-O5

Molecular Weight

  • 628.809
 

Classification Codes

  • Anti-HIV Agents
  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antiviral
  • Antiviral (HIV Protease Inhibitor)
  • Antiviral Agents
  • Cytochrome P-450 CYP3A Inhibitors
  • Cytochrome P-450 Enzyme Inhibitors
  • Enzyme Inhibitors
  • HIV Protease Inhibitors
  • Protease Inhibitors

Names and Synonyms

Name of Substance

  • Lopinavir
  • Lopinavir [USAN:USP:INN:BAN]

MeSH Heading

  • Lopinavir

Synonyms

  • (1S-(1R*(R*),3R*,4R*))-N-(4-(((2,6-Dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
  • (alphaS)-Tetrahydro-N-((alphaS)-alpha-((2S,3S)-2-hydroxy-4-phenyl-3-(2-(2,6-xylyloxy)acetamido)butyl)phenethyl)-alpha-isopropyl-2-oxo-1(2H)-pyrimidineacetamide
  • A 157378.0
  • A-157378.0
  • ABT 378
  • ABT-378
  • Aluvia
  • HSDB 8138
  • Lopinavir
  • UNII-2494G1JF75

Systematic Name

  • 1(2H)-Pyrimidineacetamide, N-((1S,3S,4S)-4-(((2,6-dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahyrdo-alpha-1-methylethyl)-2-oxo-, (alphaS)-

Mixture Name

  • Kaletra

Registry Numbers

CAS Registry Number

  • 192725-17-0

FDA UNII

  • 2494G1JF75

System Generated Number

  • 0192725170

Structure Descriptors

InChI

1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1

InChIKey

KJHKTHWMRKYKJE-SUGCFTRWSA-N

Smiles

c1(ccccc1)C[C@H](NC(COc1c(cccc1C)C)=O)[C@@H](O)C[C@@H](NC([C@@H](N1CCCNC1=O)C(C)C)=O)Cc1ccccc1