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Substance Name: Lonafarnib [USAN:INN]
RN: 193275-84-2
UNII: IOW153004F
InChIKey: DHMTURDWPRKSOA-RUZDIDTESA-N

Notes

  • Inhibitor of farnesyl protein transferase.
  • Inhibitor of farnesyl protein transferase.

    NCI: A synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers. (NCI Thesaurus)

Molecular Formula

  • C27-H31-Br2-Cl-N4-O2

Molecular Weight

  • 638.8289
 

Classification Codes

  • Chemotherapeutic (Farnesyl Transferase Inhibitor)
  • Enzyme Inhibitors
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Names and Synonyms

Name of Substance

  • Lonafarnib
  • Lonafarnib [USAN:INN]

Synonyms

  • (+)-4-(2-(4-(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-piperidin-1-yl))-2-oxoethyl)-piperidine-1-carboxamide
  • 1-Piperidinecarboxamide, 4-(2-(4-((11R-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-
  • 4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide
  • Lonafarnib
  • Sarasar
  • SCH 66336
  • SCH-66336
  • SCH66336
  • UNII-IOW153004F

Systematic Name

  • 1-Piperidinecarboxamide, 4-(2-(4-((11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-

Registry Numbers

CAS Registry Number

  • 193275-84-2

FDA UNII

  • IOW153004F

System Generated Number

  • 0193275842

Structure Descriptors

InChI

1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1

InChIKey

DHMTURDWPRKSOA-RUZDIDTESA-N

Smiles

NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]3c4ncc(Br)cc4CCc5cc(Cl)cc(Br)c35)CC1