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Substance Name: Moquizone [INN]
RN: 19395-58-5
UNII: EG12MD1RMA
InChIKey: VCRQLDNIOXNDMT-UHFFFAOYSA-N

Molecular Formula

  • C20-H21-N3-O3

Molecular Weight

  • 351.4039
 
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Names and Synonyms

Name of Substance

  • Moquizone
  • Moquizone [INN]

Synonyms

  • BRN 1231048
  • EINECS 243-021-2
  • Mochizone
  • Mochizone [DCIT]
  • Moquizona
  • Moquizona [INN-Spanish]
  • Moquizone
  • Moquizonum
  • Moquizonum [INN-Latin]
  • UNII-EG12MD1RMA

Systematic Names

  • 2,3-Dihydro-1-(morpholinoacetyl)-3-phenyl-4(1H)-quinazolinone
  • 4(1H)-Quinazolinone, 2,3-dihydro-1-(4-morpholinyacetyl)-3-phenyl -
  • 4(1H)-Quinazolinone, 2,3-dihydro-1-(morpholinoacetyl)-3-phenyl-
  • Moquizone

Registry Numbers

CAS Registry Number

  • 19395-58-5

FDA UNII

  • EG12MD1RMA

Related Registry Number

  • 19395-78-9 (hydrochloride)

System Generated Number

  • 0019395585

Structure Descriptors

InChI

1S/C20H21N3O3/c24-19(14-21-10-12-26-13-11-21)23-15-22(16-6-2-1-3-7-16)20(25)17-8-4-5-9-18(17)23/h1-9H,10-15H2

InChIKey

VCRQLDNIOXNDMT-UHFFFAOYSA-N

Smiles

c1ccc(cc1)N2CN(c3ccccc3C2=O)C(=O)CN4CCOCC4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 559mg/kg (559mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 16, Pg. 571, 1970.
mouse LD50 intravenous 237mg/kg (237mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Toxicology and Applied Pharmacology. Vol. 16, Pg. 571, 1970.
mouse LD50 oral 930mg/kg (930mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Japanese Journal of Pharmacology. Vol. 22, Pg. 235, 1972.
mouse LD50 subcutaneous 774mg/kg (774mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 16, Pg. 571, 1970.
rabbit LD50 intravenous 180mg/kg (180mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Toxicology and Applied Pharmacology. Vol. 16, Pg. 571, 1970.
rabbit LD50 oral 1730mg/kg (1730mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Toxicology and Applied Pharmacology. Vol. 16, Pg. 571, 1970.
rat LD50 intravenous 146mg/kg (146mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Toxicology and Applied Pharmacology. Vol. 16, Pg. 571, 1970.
rat LD50 oral 2220mg/kg (2220mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Toxicology and Applied Pharmacology. Vol. 16, Pg. 571, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 136 deg C   EXP
log P (octanol-water) 0.380 (none)   EST
Atmospheric OH Rate Constant 1.87E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.