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Substance Name: Moquizone hydrochloride
RN: 19395-78-9
UNII: 51I2PZ39ND
InChIKey: NUQJOBPPCCFWJG-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C20-H21-N3-O3.Cl-H

Molecular Weight

  • 387.865
 
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Names and Synonyms

Name of Substance

  • Moquizone hydrochloride

Synonyms

  • 1-Morpholinoacetyl-3-phenyl-2,3-dihydro-4(1H)quinazolinone hydrochloride
  • 2,3-Dihydro-1-(morpholinoacetyl)-3-phenyl-4(1H)-quinazolinone hydrochloride
  • EINECS 243-022-8
  • Moquizone (VAN)
  • Moquizone HCl
  • Moquizone hydrochloride
  • NSC 291563
  • Peristil
  • Rec 14-0127
  • UNII-51I2PZ39ND

Systematic Names

  • 2,3-Dihydro-1-(morpholinoacetyl)-3-phenylquinazolin-4(1H)-one monohydrochloride
  • 4(1H)-Quinazolinone, 2,3-dihydro-1-(4-morpholinylacetyl)-3-phenyl-, monohydrochloride (9CI)
  • 4(1H)-Quinazolinone, 2,3-dihydro-1-(morpholinoacetyl)-3-phenyl-, hydrochloride
  • 4(1H)-Quinazolinone, 2,3-dihydro-1-(morpholinoacetyl)-3-phenyl-, monohydrochloride (8CI)

Registry Numbers

CAS Registry Number

  • 19395-78-9

FDA UNII

  • 51I2PZ39ND

Related Registry Number

  • 19395-58-5 (Parent)

System Generated Number

  • 0019395789

Molecular Formulas

Molecular Formula

  • C20-H21-N3-O3.Cl-H

Molecular Formula Fragments

  • C20-H21-N3-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C20H21N3O3.ClH/c24-19(14-21-10-12-26-13-11-21)23-15-22(16-6-2-1-3-7-16)20(25)17-8-4-5-9-18(17)23;/h1-9H,10-15H2;1H

InChIKey

NUQJOBPPCCFWJG-UHFFFAOYSA-N

Smiles

c1cc2c(C(N(CN2C(CN2CCOCC2)=O)c2ccccc2)=O)cc1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 200mg/kg (200mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1894, 1972.
mammal (species unspecified) LD50 intraperitoneal 560mg/kg (560mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 9, Pg. 639, 1974.
mouse LD50 intraperitoneal 559mg/kg (559mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1894, 1972.
mouse LD50 intravenous 237mg/kg (237mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1894, 1972.
mouse LD50 oral 1155mg/kg (1155mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1894, 1972.
mouse LD50 subcutaneous 774mg/kg (774mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1894, 1972.
rabbit LD50 intravenous 190mg/kg (190mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1894, 1972.
rabbit LD50 oral 1650mg/kg (1650mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1894, 1972.
rat LD50 intraperitoneal 450mg/kg (450mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1894, 1972.
rat LD50 intravenous 146mg/kg (146mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1894, 1972.
rat LD50 oral 2135mg/kg (2135mg/kg) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 1894, 1972.