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Substance Name: Tetragastrin [JAN]
RN: 1947-37-1
UNII: 0OL293AV80
InChIKey: RGYLYUZOGHTBRF-BIHRQFPBSA-N

Note

  • L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalaninamide. The C-terminal tetrapeptide of gastrin. It is the smallest peptide fragment of gastrin which has the same physiological and pharmacological activity as gastrin.

Molecular Formula

  • C37-H42-N6-O8-S

Molecular Weight

  • 596.7054
 
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Names and Synonyms

Name of Substance

  • Tetragastrin
  • Tetragastrin [JAN]

MeSH Heading

  • Tetragastrin

Synonyms

  • CCRIS 3246
  • Cholecystokinin tetrapeptide
  • Gastrin tetrapeptide
  • Gastrin tetrapeptide amide
  • N-((Phenylmethoxy)carbonyl)-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalaninamide
  • Tetragastrin
  • UNII-0OL293AV80

Systematic Names

  • L-Phenylalaninamide, L-tryptophyl-L-methionyl-L-alpha-aspartyl-
  • L-Phenylalaninamide, N-((phenylmethoxy)carbonyl)-L-tryptophyl-L-methionyl-L-aspartyl-
  • L-Triptophyl-L-methyionyl-L-alpha-aspartyl-L-phenylalaninamide
  • Tetragastrin

Registry Numbers

CAS Registry Number

  • 1947-37-1

FDA UNII

  • 0OL293AV80

System Generated Number

  • 0001947371

Structure Descriptors

InChI

1S/C29H36N6O6S/c1-42-12-11-22(33-27(39)20(30)14-18-16-32-21-10-6-5-9-19(18)21)28(40)35-24(15-25(36)37)29(41)34-23(26(31)38)13-17-7-3-2-4-8-17/h2-10,16,20,22-24,32H,11-15,30H2,1H3,(H2,31,38)(H,33,39)(H,34,41)(H,35,40)(H,36,37)/t20-,22-,23-,24-/m0/s1

InChIKey

RGYLYUZOGHTBRF-BIHRQFPBSA-N

Smiles

CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 100mg/kg (100mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: EXCITEMENT
Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 121, 1969.
mouse LD intravenous > 1gm/kg (1000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 121, 1969.
mouse LD oral > 2gm/kg (2000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 121, 1969.
mouse LD subcutaneous > 2gm/kg (2000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 121, 1969.
rabbit LD intravenous > 5gm/kg (5000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 121, 1969.
rat LD50 intravenous > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. -, Pg. 816, 1995.
rat LD50 oral > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. -, Pg. 816, 1995.