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Substance Name: Benzimidazole, 2-(4-thiazolyl)-, hydrochloride
RN: 19525-20-3
InChIKey: XRBJCVRLNRBXHG-UHFFFAOYSA-N

Note

  • 2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for STRONGYLOIDIASIS. It has CENTRAL NERVOUS SYSTEM side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)

Molecular Formulas

  • C10-H7-N3-S.Cl-H
  • C10-H7-N3-S.x-Cl-H

Molecular Weight

  • 237.713
 
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Names and Synonyms

Synonyms

  • 2-(4-Thiazolyl)benzimidazole hydrochloride
  • EINECS 243-132-6
  • Thiabendazole hydrochloride

Systematic Names

  • Benzimidazole, 2-(4-thiazolyl)-, hydrochloride
  • Tiabendazole hydrochloride

Registry Numbers

CAS Registry Number

  • 19525-20-3

System Generated Number

  • 0019525203

Molecular Formulas

Molecular Formulas

  • C10-H7-N3-S.Cl-H
  • C10-H7-N3-S.x-Cl-H

Molecular Formula Fragments

  • C10-H7-N3-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C10H7N3S.ClH/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9;/h1-6H,(H,12,13);1H

InChIKey

XRBJCVRLNRBXHG-UHFFFAOYSA-N

Smiles

c1(nc2ccccc2[nH]1)c1ncsc1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 430mg/kg (430mg/kg)   Toxicology and Applied Pharmacology. Vol. 7, Pg. 53, 1965.
mouse LD50 intravenous 160mg/kg (160mg/kg) BEHAVIORAL: ATAXIA

GASTROINTESTINAL: NAUSEA OR VOMITING
Toxicology and Applied Pharmacology. Vol. 7, Pg. 53, 1965.
mouse LD50 oral 2400mg/kg (2400mg/kg)   Toxicology and Applied Pharmacology. Vol. 7, Pg. 53, 1965.
rat LD50 intraperitoneal 1850mg/kg (1850mg/kg)   Toxicology and Applied Pharmacology. Vol. 7, Pg. 53, 1965.
rat LD50 intravenous 180mg/kg (180mg/kg) BEHAVIORAL: ATAXIA

GASTROINTESTINAL: NAUSEA OR VOMITING
Toxicology and Applied Pharmacology. Vol. 7, Pg. 53, 1965.
rat LD50 oral 3600mg/kg (3600mg/kg)   Toxicology and Applied Pharmacology. Vol. 7, Pg. 53, 1965.