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Substance Name: Ranpirnase [USAN:INN]
RN: 196488-72-9
UNII: ZE15FIT23E
InChIKey: UAXPHLMVFGUJGD-QXWQFOMJSA-N

Note

  • Pannon is a paritally purified extract of ranpirnase; P-30 is a 15kDa protein isolated from Pannon; it is an anti-tumor amphibian oocyte RNase found in Rana pipiens eggs and early embryos.

Molecular Formula

  • C520-H810-N142-O155-S9

Molecular Weight

  • 11819.552
 

Classification Codes

  • Antineoplastic Agents
  • Antineoplastic for the Treatment of Solid Tumors
  • Enzyme Inhibitors
  • Protein Synthesis Inhibitors
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Names and Synonyms

Name of Substance

  • Ranpirnase
  • Ranpirnase [USAN:INN]

Synonyms

  • Onconase
  • P-30 Protein
  • Ranpirnase
  • Ribonuclease (Rana pipiens)
  • UNII-ZE15FIT23E

Systematic Name

  • Ribonuclease (Rana pipiens)

Registry Numbers

CAS Registry Number

  • 196488-72-9

FDA UNII

  • ZE15FIT23E

System Generated Number

  • 0196488729

Structure Descriptors

InChI

1S/C520H810N142O155S9/c1-53-259(33)401-501(800)648-402(260(34)54-2)497(796)563-265(39)417(716)620-351(228-664)471(770)575-304(132-87-99-176-529)429(728)602-339(209-375(538)689)464(763)638-395(253(21)22)492(791)611-322(192-250(15)16)460(759)652-416(277(51)680)512(811)658-414(275(49)678)510(809)625-354(231-667)472(771)580-312(158-164-384(698)699)435(734)594-323(193-278-110-65-59-66-111-278)444(743)596-327(200-285-145-151-292(682)152-146-285)443(742)589-320(190-248(11)12)440(739)623-353(230-666)475(774)609-347(217-390(710)711)457(756)628-359-236-820-821-237-360(629-458(757)348(218-391(712)713)619-493(792)396(254(23)24)639-469(768)349(219-392(714)715)608-431(730)308(136-103-180-552-518(543)544)583-503(802)407(268(42)671)650-468(767)343(213-379(542)693)618-508(807)412(273(47)676)657-502(801)406(264(38)58-6)647-463(762)335(205-290-223-551-245-561-290)599-427(726)300(128-83-95-172-525)568-422(721)298(126-81-93-170-523)570-434(733)311(156-162-371(534)685)579-442(741)328(196-281-116-71-62-72-117-281)613-504(803)408(269(43)672)649-459(758)321(191-249(13)14)591-448(747)332(202-287-220-555-295-123-78-77-122-294(287)295)598-455(754)345(215-388(706)707)607-433(732)309-157-163-380(694)565-309)483(782)610-346(216-389(708)709)456(755)604-341(211-377(540)691)466(765)646-404(262(36)56-4)498(797)584-314(167-187-818-52)437(736)622-357(234-670)477(776)654-411(272(46)675)507(806)617-338(208-374(537)688)453(752)590-319(189-247(9)10)439(738)595-324(194-279-112-67-60-68-113-279)445(744)600-333(203-288-221-549-243-559-288)450(749)627-358-235-819-822-238-361(631-486(785)367-140-108-185-661(367)515(814)316(138-105-182-554-520(547)548)586-474(773)355(232-668)626-509(808)413(274(48)677)655-495(794)399(257(29)30)640-465(764)340(210-376(539)690)605-482(359)781)479(778)577-305(133-88-100-177-530)426(725)593-326(199-284-143-149-291(681)150-144-284)441(740)572-301(129-84-96-173-526)424(723)588-318(188-246(7)8)438(737)571-299(127-82-94-171-524)423(722)569-307(135-90-102-179-532)432(731)621-356(233-669)476(775)653-410(271(45)674)506(805)616-337(207-373(536)687)452(751)573-302(130-85-97-174-527)425(724)592-325(195-280-114-69-61-70-115-280)447(746)630-364-241-825-826-242-365(517(816)817)634-470(769)350(227-663)566-381(695)224-557-489(788)393(251(17)18)635-382(696)226-558-490(789)394(252(19)20)637-461(760)330(197-282-118-73-63-74-119-282)597-449(748)334(204-289-222-550-244-560-289)615-494(793)398(256(27)28)643-487(786)368-141-106-183-659(368)513(812)267(41)564-421(720)310(155-161-370(533)684)578-451(750)336(206-372(535)686)601-436(735)313(159-165-385(700)701)581-481(780)363(633-511(810)415(276(50)679)656-496(795)400(258(31)32)641-484(364)783)240-824-823-239-362(480(779)567-296(124-79-91-168-521)419(718)556-225-383(697)636-401)632-500(799)403(261(35)55-3)644-418(717)266(40)562-420(719)297(125-80-92-169-522)582-491(790)397(255(25)26)642-488(787)369-142-109-186-662(369)516(815)317(160-166-386(702)703)587-485(784)366-139-107-184-660(366)514(813)315(137-104-181-553-519(545)546)585-473(772)352(229-665)624-446(745)329(201-286-147-153-293(683)154-148-286)612-499(798)405(263(37)57-5)645-462(761)331(198-283-120-75-64-76-121-283)614-505(804)409(270(44)673)651-467(766)342(212-378(541)692)603-428(727)303(131-86-98-175-528)574-454(753)344(214-387(704)705)606-430(729)306(576-478(358)777)134-89-101-178-531/h59-78,110-123,143-154,220-223,243-277,296-369,393-416,555,663-683H,53-58,79-109,124-142,155-219,224-242,521-532H2,1-52H3,(H2,533,684)(H2,534,685)(H2,535,686)(H2,536,687)(H2,537,688)(H2,538,689)(H2,539,690)(H2,540,691)(H2,541,692)(H2,542,693)(H,549,559)(H,550,560)(H,551,561)(H,556,718)(H,557,788)(H,558,789)(H,562,719)(H,563,796)(H,564,720)(H,565,694)(H,566,695)(H,567,779)(H,568,721)(H,569,722)(H,570,733)(H,571,737)(H,572,740)(H,573,751)(H,574,753)(H,575,770)(H,576,777)(H,577,778)(H,578,750)(H,579,741)(H,580,771)(H,581,780)(H,582,790)(H,583,802)(H,584,797)(H,585,772)(H,586,773)(H,587,784)(H,588,723)(H,589,742)(H,590,752)(H,591,747)(H,592,724)(H,593,725)(H,594,734)(H,595,738)(H,596,743)(H,597,748)(H,598,754)(H,599,726)(H,600,744)(H,601,735)(H,602,728)(H,603,727)(H,604,755)(H,605,781)(H,606,729)(H,607,732)(H,608,730)(H,609,774)(H,610,782)(H,611,791)(H,612,798)(H,613,803)(H,614,804)(H,615,793)(H,616,805)(H,617,806)(H,618,807)(H,619,792)(H,620,716)(H,621,731)(H,622,736)(H,623,739)(H,624,745)(H,625,809)(H,626,808)(H,627,749)(H,628,756)(H,629,757)(H,630,746)(H,631,785)(H,632,799)(H,633,810)(H,634,769)(H,635,696)(H,636,697)(H,637,760)(H,638,763)(H,639,768)(H,640,764)(H,641,783)(H,642,787)(H,643,786)(H,644,717)(H,645,761)(H,646,765)(H,647,762)(H,648,800)(H,649,758)(H,650,767)(H,651,766)(H,652,759)(H,653,775)(H,654,776)(H,655,794)(H,656,795)(H,657,801)(H,658,811)(H,698,699)(H,700,701)(H,702,703)(H,704,705)(H,706,707)(H,708,709)(H,710,711)(H,712,713)(H,714,715)(H,816,817)(H4,543,544,552)(H4,545,546,553)(H4,547,548,554)/t259-,260-,261-,262-,263-,264-,265-,266-,267-,268+,269+,270+,271+,272+,273+,274+,275+,276+,277+,296-,297-,298-,299-,300-,301-,302-,303-,304-,305-,306-,307-,308-,309-,310-,311-,312-,313-,314-,315-,316-,317-,318-,319-,320-,321-,322-,323-,324-,325-,326-,327-,328-,329-,330-,331-,332-,333-,334-,335-,336-,337-,338-,339-,340-,341-,342-,343-,344-,345-,346-,347-,348-,349-,350-,351-,352-,353-,354-,355-,356-,357-,358-,359-,360-,361-,362-,363-,364-,365-,366-,367-,368-,369-,393-,394-,395-,396-,397-,398-,399-,400-,401-,402-,403-,404-,405-,406-,407-,408-,409-,410-,411-,412-,413-,414-,415-,416-/m0/s1

InChIKey

UAXPHLMVFGUJGD-QXWQFOMJSA-N

Smiles

CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]3CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]4CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]5CCCN5C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N1)CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]6CCCN6C(=O)[C@@H](NC(=O)[C@@H]7CCCN7C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC3=O)CCCCN)CC(=O)O)CCCCN)CC(=O)N)[C@@H](C)O)Cc8ccccc8)[C@@H](C)CC)Cc9ccc(cc9)O)CO)CCCNC(=N)N)CCC(=O)O)C(C)C)CCCCN)C)[C@@H](C)CC)NC(=O)[C@@H](NC(=O)[C@@H](NC4=O)C(C)C)[C@@H](C)O)CCC(=O)O)CC(=O)N)CCC(=O)N)C)C(C)C)Cc1cnc[nH]1)Cc1ccccc1)C(C)C)C(C)C)CO)C(=O)O)Cc1ccccc1)CCCCN)CC(=O)N)[C@@H](C)O)CO)CCCCN)CCCCN)CC(C)C)CCCCN)Cc1ccc(cc1)O)CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CC(=O)N)C(C)C)[C@@H](C)O)CO)CCCNC(=N)N)Cc1cnc[nH]1)Cc1ccccc1)CC(C)C)CC(=O)N)[C@@H](C)O)CO)CCSC)[C@@H](C)CC)CC(=O)N)CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCC(=O)N1)CC(=O)O)CO)CC(C)C)Cc1ccc(cc1)O)Cc1ccccc1)CCC(=O)O)CO)[C@@H](C)O)[C@@H](C)O)CC(C)C)C(C)C)CC(=O)N)CCCCN)CO)C)[C@@H](C)CC