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Substance Name: CCX-872
RN: 1966966-88-0


  • NCI: CCR2 antagonist CCX872-B An orally available human C-C chemokine receptor type 2 (CCR2) antagonist, with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist CCX872-B specifically binds to CCR2 and prevents the binding to its cognate endothelium-derived chemokine ligand CCL2 (monocyte chemoattractant protein-1 or MCP1). This may result in the inhibition of both CCR2 activation and CCR2-mediated signal transduction, which may inhibit inflammatory processes, angiogenesis, tumor cell migration, and tumor cell proliferation. The G-protein coupled receptor CCR2 is expressed on the surface of monocytes and macrophages, and stimulates their migration and infiltration; it plays a key role in inflammation. CCR2 is overexpressed in certain cancer cell types, where it is involved in angiogenesis, tumor cell migration and proliferation. (NCI Thesaurus)
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Names and Synonyms

Name of Substance

  • CCX-872


  • CCX872
  • CCX872-B

Registry Numbers

CAS Registry Number

  • 1966966-88-0

System Generated Number

  • 1966966880