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Substance Name: 10-Hydroxycamptothecin
RN: 19685-09-7
UNII: 9Z01632KRV
InChIKey: HAWSQZCWOQZXHI-FQEVSTJZSA-N

Classification Codes

  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Drug / Therapeutic Agent
  • Mutation Data
  • Natural Product

Molecular Formulas

  • C20-H16-N2-O5
  • C20-H16-N2-O5.H2-O

Molecular Weight

  • 364.3554
 
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Names and Synonyms

Name of Substance

  • 10-Hydroxycamptothecin

Synonyms

  • (S)-10-Hydroxycamptothecin hydrate
  • 10-Hydroxycamptothecin
  • 10-Hydroxycamptothecine
  • Camptothecin, 10-hydroxy-
  • Camptothecin, hydroxy-
  • Hydroxycamptothecin
  • Hydroxycamptothecine
  • NSC 107124
  • UNII-9Z01632KRV

Systematic Names

  • 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, hydrate, (S)-
  • 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione-,4-ethyl-4,9-dihydroxy-, (S)- (9CI)
  • Camptothecine, 10-hydroxy- (8CI)

Registry Numbers

CAS Registry Number

  • 19685-09-7

FDA UNII

  • 9Z01632KRV

Other Registry Numbers

  • 104155-90-0
  • 157405-42-0

System Generated Number

  • 0019685097

Molecular Formulas

Molecular Formulas

  • C20-H16-N2-O5
  • C20-H16-N2-O5.H2-O

Molecular Formula Fragments

  • C20-H16-N2-O5
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1

InChIKey

HAWSQZCWOQZXHI-FQEVSTJZSA-N

Smiles

CC[C@@]1(c2cc-3n(c(=O)c2COC1=O)Cc4c3nc5ccc(cc5c4)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 104mg/kg (104mg/kg)   Drugs of the Future. Vol. 7, Pg. 629, 1982.
rat LD intravenous > 10mg/kg (10mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

KIDNEY, URETER, AND BLADDER: HEMATURIA
Cancer Chemotherapy and Pharmacology. Vol. 41, Pg. 257, 1998.