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Substance Name: Metitepine maleate
RN: 19728-88-2
UNII: LVP2XBC3GA
InChIKey: IWDBEHWZGDSFHR-BTJKTKAUSA-N

Note

  • A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H24-N2-S2.C4-H4-O4

Molecular Weight

  • 472.6272
 
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Names and Synonyms

Name of Substance

  • Metitepine maleate

Synonyms

  • 1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine maleate
  • 8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin maleate
  • Dibenzo(b,f)thiepin, 10,11-dihydro-10-(4-methylpiperazino)-8-methylthio-, hydrogen maleate
  • Dibenzo(b,f)thiepin, 10,11-dihydro-8-methylthio-10-(4-methylpiperazino)-, hydrogen maleate
  • Methiothepin maleate
  • Metitepin maleate
  • Ro 8-6837
  • UNII-LVP2XBC3GA
  • VUFB 6276

Systematic Name

  • Piperazine, 1-(10,11-dihydro-8-methylthiodibenzo(b,f)thiepin-10-yl)-4-methyl-, maleate (1:1)

Registry Numbers

CAS Registry Number

  • 19728-88-2

FDA UNII

  • LVP2XBC3GA

System Generated Number

  • 0019728882

Molecular Formulas

Molecular Formula

  • C20-H24-N2-S2.C4-H4-O4

Molecular Formula Fragments

  • C20-H24-N2-S2
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C20H24N2S2.C4H4O4/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;5-3(6)1-2-4(7)8/h3-8,14,18H,9-13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChIKey

IWDBEHWZGDSFHR-BTJKTKAUSA-N

Smiles

CN1CCN(CC1)C2Cc3ccccc3Sc4c2cc(cc4)SC.C(=C\C(=O)O)\C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 67600ug/kg (67.6mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Collection of Czechoslovak Chemical Communications. Vol. 39, Pg. 3153, 1974.
mouse LD50 oral 125mg/kg (125mg/kg) BEHAVIORAL: ATAXIA Collection of Czechoslovak Chemical Communications. Vol. 39, Pg. 3338, 1974.