Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Mesna [USAN:USP:INN:BAN]
RN: 19767-45-4
UNII: NR7O1405Q9
InChIKey: XOGTZOOQQBDUSI-UHFFFAOYSA-M

Note

  • A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.

Molecular Formulas

  • C2-H5-Na-O3-S2
  • C2-H5-O3-S2.Na
  • C2-H6-O3-S2.Na

Molecular Weight

  • 164.1805
 

Classification Codes

  • Detoxifying Agent
  • Drug / Therapeutic Agent
  • Protective Agents
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Mesna
  • Mesna [USAN:USP:INN:BAN]

MeSH Heading

  • Mesna

Synonyms

  • 2-Mercapto-ethan-sulfonsaeure, natrium-salz
  • 2-Mercaptoethane sulfonate sodium
  • 2-Mercaptoethanesulfonic acid monosodium salt
  • 2-Mercaptoethanesulfonic acid sodium salt
  • CCRIS 3712
  • D 7093
  • EINECS 243-285-9
  • Mesna
  • Mesnex
  • Mesnum
  • Mesnum [INN-Latin]
  • Mistabron
  • Mistabronco
  • Mitexan
  • Mucofluid
  • Natrium 2-mercaptoethansulfonat
  • NSC 113891
  • Sodium 2-mercaptoethanesulfonate
  • UNII-NR7O1405Q9
  • Uromitexan

Systematic Names

  • Ethanesulfonic acid, 2-mercapto-, monosodium salt
  • Mesna
  • Sodium 2-mercaptoethane sulfonate

Registry Numbers

CAS Registry Number

  • 19767-45-4

FDA UNII

  • NR7O1405Q9

Related Registry Number

  • 3375-50-6 (parent cpd)

System Generated Number

  • 0019767454

Molecular Formulas

Molecular Formulas

  • C2-H5-Na-O3-S2
  • C2-H5-O3-S2.Na
  • C2-H6-O3-S2.Na

Molecular Formula Fragments

  • C2-H5-O3-S2
  • C2-H6-O3-S2
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C2H6O3S2.Na/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5);/q;+1/p-1

InChIKey

XOGTZOOQQBDUSI-UHFFFAOYSA-M

Smiles

C(CS(=O)(=O)[O-])S.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 2gm/kg (2000mg/kg)   European Journal of Cancer and Clinical Oncology. Vol. 18, Pg. 1377, 1982.
dog LDLo intravenous 400mg/kg (400mg/kg)   European Journal of Cancer and Clinical Oncology. Vol. 18, Pg. 1377, 1982.
dog LDLo intravenous 400mg/kg (400mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
European Journal of Cancer and Clinical Oncology. Vol. 18, Pg. 1377, 1982.
mouse LD50 intraperitoneal 2005mg/kg (2005mg/kg)   European Journal of Cancer and Clinical Oncology. Vol. 18, Pg. 1377, 1982.
mouse LD50 intravenous 1720mg/kg (1720mg/kg) BLOOD: CHANGES IN SPLEEN

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 25, Pg. 5, 1991.
mouse LD50 oral 6102mg/kg (6102mg/kg)   European Journal of Cancer and Clinical Oncology. Vol. 18, Pg. 1377, 1982.
mouse LD50 subcutaneous 1200mg/kg (1200mg/kg)   Farmakologiya i Toksikologiya Vol. 23, Pg. 355, 1960.
rat LD50 intraperitoneal 1251mg/kg (1251mg/kg)   European Journal of Cancer and Clinical Oncology. Vol. 18, Pg. 1377, 1982.
rat LD50 intravenous 1510mg/kg (1510mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 25, Pg. 5, 1991.
rat LD50 oral 4440mg/kg (4440mg/kg)   European Journal of Cancer and Clinical Oncology. Vol. 18, Pg. 1377, 1982.
rat LD50 subcutaneous 2313mg/kg (2313mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Kiso to Rinsho. Clinical Report. Vol. 25, Pg. 5, 1991.