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Substance Name: Perlapine [USAN:INN:BAN:JAN]
RN: 1977-11-3
UNII: 4N8UJJ27IM
InChIKey: PWRPUAKXMQAFCJ-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Sedative-Hypnotic

Molecular Formula

  • C19-H21-N3

Molecular Weight

  • 291.396
 
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Names and Synonyms

Name of Substance

  • Perlapine
  • Perlapine [USAN:INN:BAN:JAN]

Synonyms

  • 11H-Dibenz(b,e)azepine, 6-(4-methyl-1-piperazinyl)-
  • 5-23-03-00089 (Beilstein Handbook Reference)
  • 6-(4-Methyl-1-piperazinyl)-11H-dibenz(b,e)azepine
  • 6-(4-Methyl-1-piperazinyl)morfantridin
  • 6-(4-Methyl-1-piperazinyl)morphanthridine
  • AW 14'2333
  • AW-14'2333
  • BRN 0434631
  • HF-2333
  • Hypnodin
  • Morphanthridine, 6-(4-methyl-1-piperazinyl)-
  • MP-11
  • NSC 291840
  • Perlapin
  • Perlapina
  • Perlapina [INN-Spanish]
  • Perlapina [Spanish]
  • Perlapine
  • Perlapinum
  • Perlapinum [INN-Latin]
  • UNII-4N8UJJ27IM

Systematic Names

  • 11H-Dibenz(b,e)azepine, 6-(4-methyl-1-piperazinyl)-
  • Morphanthridine, 6-(4-methyl-1-piperazinyl)- (8CI)

Registry Numbers

CAS Registry Number

  • 1977-11-3

FDA UNII

  • 4N8UJJ27IM

System Generated Number

  • 0001977113

Structure Descriptors

InChI

1S/C19H21N3/c1-21-10-12-22(13-11-21)19-17-8-4-2-6-15(17)14-16-7-3-5-9-18(16)20-19/h2-9H,10-14H2,1H3

InChIKey

PWRPUAKXMQAFCJ-UHFFFAOYSA-N

Smiles

C=1(c2c(Cc3c(N1)cccc3)cccc2)N1CCN(C)CC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 unreported 680mg/kg (680mg/kg)   Medicamentos de Actualidad. Vol. 11, Pg. 76, 1975.
mouse LD50 intraperitoneal 215mg/kg (215mg/kg)   United States Patent Document. Vol. #4376773,
mouse LD50 intravenous 61mg/kg (61mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 193, 1973.
mouse LD50 oral 270mg/kg (270mg/kg)   Drugs in Japan Vol. 6, Pg. 770, 1982.
mouse LD50 subcutaneous 250mg/kg (250mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 193, 1973.
rat LD50 intravenous 60mg/kg (60mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 193, 1973.
rat LD50 oral 660mg/kg (660mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 193, 1973.
rat LD50 subcutaneous 420mg/kg (420mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 193, 1973.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 137 deg C   EXP
log P (octanol-water) 2.920 (none)   EST
Atmospheric OH Rate Constant 1.88E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.