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Substance Name: Amiodarone hydrochloride [USP:JAN]
RN: 19774-82-4
UNII: 976728SY6Z
InChIKey: ITPDYQOUSLNIHG-UHFFFAOYSA-N

Note

  • An antianginal and antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting Na,K-activated myocardial adenosine triphosphatase. There is a resulting decrease in heart rate and in vascular resistance.

Molecular Formula

  • C25-H29-I2-N-O3.Cl-H

Molecular Weight

  • 681.769
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Names and Synonyms

Results Name

  • Amiodarone hydrochloride [USP:JAN]

Name of Substance

  • Amiodarone hydrochloride
  • Amiodarone hydrochloride [JAN]
  • Amiodarone hydrochloride [USP:JAN]

Synonyms

  • 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone hydrochloride
  • 51087 N HCl
  • Amiodar
  • Amiodarone HCl
  • Amiodarone hydrochloride
  • Amiodaronum hydrochloride
  • Angoron
  • Atlansil
  • Cordarex
  • Cordarone
  • EINECS 243-293-2
  • HSDB 6525
  • L 3428
  • L 3428 labaz
  • Miodrone
  • Nexterone
  • NSC 85442
  • Pacerone
  • Renodoron
  • Ritmocardyl
  • Rythmarone
  • SKF 33134 A
  • SKF 33134-A
  • Trangorex
  • UNII-976728SY6Z
  • Uro-septra

Systematic Names

  • 2-Butyl-3-benzofuryl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone hydrochloride
  • Ketone, 2-butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl, hydrochloride
  • Methanone, (2-butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)-, hydrochloride (9CI)

Superlist Name

  • Amiodarone hydrochloride

Registry Numbers

CAS Registry Number

  • 19774-82-4

FDA UNII

  • 976728SY6Z

System Generated Number

  • 0019774824

Molecular Formulas

Molecular Formula

  • C25-H29-I2-N-O3.Cl-H

Molecular Formula Fragments

  • C25-H29-I2-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H

InChIKey

ITPDYQOUSLNIHG-UHFFFAOYSA-N

Smiles

Cl.CCCCc1oc2ccccc2c1C(=O)c3cc(I)c(OCCN(CC)CC)c(I)c3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 5gm/kg (5000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
dog LD50 oral > 5gm/kg (5000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
man LDLo oral 3129mg/kg/3Y- (3129mg/kg) LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Southern Medical Journal. Vol. 89, Pg. 85, 1996.
man TDLo oral 171mg/kg/30D- (171mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
American Heart Journal. Vol. 100, Pg. 412, 1980.
man TDLo oral 240mg/kg/6W-I (240mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Archives of Internal Medicine. Vol. 155, Pg. 1106, 1995.
mouse LD50 intraperitoneal 450mg/kg (450mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
mouse LD50 oral > 3gm/kg (3000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
rat LD50 intraperitoneal 610mg/kg (610mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
rat LD50 intravenous 170mg/kg (170mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
rat LD50 oral > 3gm/kg (3000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
women TDLo oral 120mg/kg/10D- (120mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) Human Toxicology. Vol. 4, Pg. 169, 1985.
women TDLo oral 1128mg/kg/56W (1128mg/kg)   American Journal of Medicine. Vol. 86, Pg. 134, 1989.
women TDLo oral 1128mg/kg/56W (1128mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"
American Journal of Medicine. Vol. 86, Pg. 134, 1989.
women TDLo oral 2480mg/kg/43W (2480mg/kg) ENDOCRINE: THYROID WEIGHT (GOITER) Acta Medica Scandinavica. Vol. 221, Pg. 219, 1987.