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Substance Name: Homochlorcyclizine dihydrochloride
RN: 1982-36-1
UNII: M1YE3TK8NA
InChIKey: JLVFQWFTNVMTEG-UHFFFAOYSA-N

Molecular Formula

  • C19-H23-Cl-N2.2Cl-H

Molecular Weight

  • 387.78
 
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Names and Synonyms

Name of Substance

  • Homochlorcyclizine dihydrochloride

Synonyms

  • 1-(p-Chloro-alpha-phenylbenzyl)hexahydro-4-methyl-1H-1,4-diazepine, dihydrochloride
  • 1-H,4-Diazepine, 1-(p-chloro-alpha-phenylbenzyl)hexahydro-4-methyl-, dihydrochloride
  • Homochlorcyclizine HCl
  • Homochlorcyclizine, dihydrochloride
  • Homochlorcyclizine, hydrochloride (VAN)
  • NSC 169498
  • SA 97 dihydrochloride
  • SA-97
  • UNII-M1YE3TK8NA

Systematic Name

  • 1H-1,4-Diazepine, 1-(p-chloro-alpha-phenylbenzyl)hexahydro-4-methyl-, dihydrochloride

Registry Numbers

CAS Registry Number

  • 1982-36-1

FDA UNII

  • M1YE3TK8NA

System Generated Number

  • 0001982361

Molecular Formulas

Molecular Formula

  • C19-H23-Cl-N2.2Cl-H

Molecular Formula Fragments

  • C19-H23-Cl-N2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H23ClN2.2ClH/c1-21-12-5-13-22(15-14-21)19(16-6-3-2-4-7-16)17-8-10-18(20)11-9-17;;/h2-4,6-11,19H,5,12-15H2,1H3;2*1H

InChIKey

JLVFQWFTNVMTEG-UHFFFAOYSA-N

Smiles

c1([C@@H]([N@@H+]2CC[N@@H+](C)CCC2)c2ccccc2)ccc(Cl)cc1.[ClH-].[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intraperitoneal 50mg/kg (50mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Allergy. Vol. 31, Pg. 237, 1960.
dog LD50 intraperitoneal 50mg/kg (50mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Allergy. Vol. 31, Pg. 237, 1960.
dog LD50 intravenous 20mg/kg (20mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: ATAXIA
Journal of Allergy. Vol. 31, Pg. 237, 1960.
guinea pig LD50 intraperitoneal 76mg/kg (76mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Allergy. Vol. 31, Pg. 237, 1960.
guinea pig LD50 intravenous 19mg/kg (19mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: TREMOR
Journal of Allergy. Vol. 31, Pg. 237, 1960.
guinea pig LD50 oral 390mg/kg (390mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Journal of Allergy. Vol. 31, Pg. 237, 1960.
mouse LD50 intraperitoneal 125mg/kg (125mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: EXCITEMENT
Journal of Allergy. Vol. 31, Pg. 237, 1960.
mouse LD50 intravenous 47mg/kg (47mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR
Journal of Allergy. Vol. 31, Pg. 237, 1960.
mouse LD50 oral 390mg/kg (390mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: EXCITEMENT
Journal of Allergy. Vol. 31, Pg. 237, 1960.
mouse LD50 subcutaneous 135mg/kg (135mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: EXCITEMENT
Journal of Allergy. Vol. 31, Pg. 237, 1960.
rabbit LD50 intravenous 20mg/kg (20mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Journal of Allergy. Vol. 31, Pg. 237, 1960.
rat LD50 intraperitoneal 80mg/kg (80mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

BEHAVIORAL: EXCITEMENT
Journal of Allergy. Vol. 31, Pg. 237, 1960.
rat LD50 intravenous 36mg/kg (36mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Journal of Allergy. Vol. 31, Pg. 237, 1960.
rat LD50 oral 490mg/kg (490mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: EXCITEMENT
Journal of Allergy. Vol. 31, Pg. 237, 1960.