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Substance Name: Methdilazine [USP:INN:BAN]
RN: 1982-37-2
UNII: 4Q13LY9Z8X
InChIKey: HTMIBDQKFHUPSX-UHFFFAOYSA-N

Classification Codes

  • Antipruritic
  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C18-H20-N2-S

Molecular Weight

  • 296.436
 
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Names and Synonyms

Name of Substance

  • Methdilazine
  • Methdilazine [USP:INN:BAN]

Synonyms

  • 10-((1-Methyl-3-pyrrolidinyl)methyl)phenothiazine
  • 10H-Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-
  • EINECS 217-841-6
  • Methdilazine
  • Methdilazinum
  • Methdilazinum [INN-Latin]
  • Metodilazina
  • Metodilazina [INN-Spanish]
  • NCI-C60720
  • Tacaryl
  • UNII-4Q13LY9Z8X

Systematic Names

  • 10H-Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-
  • Methdilazine
  • Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-

Registry Numbers

CAS Registry Number

  • 1982-37-2

FDA UNII

  • 4Q13LY9Z8X

Related Registry Number

  • 1229-35-2 (hydrochloride)

System Generated Number

  • 0001982372

Structure Descriptors

InChI

1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3

InChIKey

HTMIBDQKFHUPSX-UHFFFAOYSA-N

Smiles

CN1CCC(C1)CN2c3ccccc3Sc4c2cccc4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 263mg/kg (263mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 29, 1972.
human TDLo oral 4mg/kg (4mg/kg) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 379, 1969.
mouse LD50 intraperitoneal 183mg/kg (183mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 29, 1972.
mouse LD50 oral 225mg/kg (225mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 29, 1972.
rat LD50 oral 162mg/kg (162mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 87-88 deg C   EXP
log P (octanol-water) 5.23 (none)   EXP
Water Solubility 0.348 mg/L 25 EST
Vapor Pressure 1.73E-07 mm Hg 25 EST
Henry's Law Constant 2.91E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.75E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.