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Substance Name: Lisuride maleate [JAN]
RN: 19875-60-6
UNII: UV1635N8XW
InChIKey: CVQFAMQDTWVJSV-BAXNFHPCSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Molecular Formula

  • C20-H26-N4-O.C4-H4-O4

Molecular Weight

  • 454.524
 
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Names and Synonyms

Name of Substance

  • Lisuride maleate
  • Lisuride maleate [JAN]

Synonyms

  • 1-((5R,8S)-6-Methyl-9,10-didehydro-8-ergolinyl)-3,3-diethylurea hydrogen maleate
  • 3-(9,10-Didehydro-6-methylergolin-8-alpha-yl)-1,1-diethylurea maleate (1:1)
  • 3-(9,10-Didehydro-6-methylergolin-8-yl)-1,1-diethylurea hydrogen maleate
  • Cuvalit
  • EINECS 243-387-3
  • Lisuride hydrogen maleate
  • Lisuride maleate
  • Lysenyl
  • Lysenyl bimaleate
  • Lysenyl hydrogen maleate
  • UNII-UV1635N8XW
  • Urea, N'-((8-alpha)-9,10-didehydro-6-methylergolin-8-yl)-N,N-diethyl-, (Z)-2-butenedioate

Systematic Names

  • Lisuride hydrogen maleate
  • Urea, 3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethyl-, maleate (1:1)

Registry Numbers

CAS Registry Number

  • 19875-60-6

FDA UNII

  • UV1635N8XW

Related Registry Number

  • 18016-80-3 (Parent)

System Generated Number

  • 0019875606

Molecular Formulas

Molecular Formula

  • C20-H26-N4-O.C4-H4-O4

Molecular Formula Fragments

  • C20-H26-N4-O
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C20H26N4O.C4H4O4/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14;5-3(6)1-2-4(7)8/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,18+;/m0./s1

InChIKey

CVQFAMQDTWVJSV-BAXNFHPCSA-N

Smiles

c12c3c(ccc2)C=2[C@@H](Cc3c[nH]1)[N@@](C)C[C@H](C2)NC(N(CC)CC)=O.OC(\C=C/C(O)=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 714ng/kg (0.000714mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: HEADACHE
Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 220, 1966.
man TDLo intravenous 1429ng/kg/3M- (0.001429mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

CARDIAC: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER
Chest. Vol. 91, Pg. 792, 1987.
mouse LD50 intravenous 14800ug/kg (14.8mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TREMOR
Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 1165, 1981.
mouse LD50 oral 90mg/kg (90mg/kg)   United States Patent Document. Vol. #3681497,
mouse LD50 subcutaneous 82mg/kg (82mg/kg)   United States Patent Document. Vol. #3681497,
rabbit LD50 oral 123mg/kg (123mg/kg) BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: TREMOR
Kiso to Rinsho. Clinical Report. Vol. 15, Pg. 1165, 1981.
rat LD50 intravenous 1500ug/kg (1.5mg/kg)   United States Patent Document. Vol. #3681497,
rat LD50 oral 12500ug/kg (12.5mg/kg)   United States Patent Document. Vol. #3681497,
rat LD50 subcutaneous 3mg/kg (3mg/kg)   United States Patent Document. Vol. #3681497,