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Substance Name: Dihydromethysticin
RN: 19902-91-1
UNII: FZ66MQ73GS
InChIKey: RSIWXFIBHXYNFM-NSHDSACASA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H16-O5

Molecular Weight

  • 276.286
 
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Names and Synonyms

Name of Substance

  • Dihydromethysticin

Synonyms

  • 2H-Pyran-2-one, 6-(2-(1,3-benzodioxol-5-yl)ethyl)-5,6-dihydro-4-methoxy-, (S)-
  • 7,8-Dihydromethysticin
  • CCRIS 9368
  • DHM
  • Dihydromethysticin
  • Dihydromethysticin (VAN)
  • Methysticin, 7,8-dihydro-
  • NSC 112159
  • UNII-FZ66MQ73GS

Systematic Names

  • 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(3,4-(methylenedioxy)phenethyl)-, (S)-
  • 2H-Pyran-2-one, 6-(2-(1,3-benzodioxol-5-yl)ethyl)-5,6-dihydro-4-methoxy-, (S)- (9CI)

Registry Numbers

CAS Registry Number

  • 19902-91-1

FDA UNII

  • FZ66MQ73GS

System Generated Number

  • 0019902911

Structure Descriptors

InChI

1S/C15H16O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h3,5-6,8,11H,2,4,7,9H2,1H3/t11-/m0/s1

InChIKey

RSIWXFIBHXYNFM-NSHDSACASA-N

Smiles

c12cc(CC[C@H]3CC(=CC(O3)=O)OC)ccc2OCO1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intraperitoneal > 200mg/kg (200mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962.
mouse LD50 intraperitoneal 420mg/kg (420mg/kg)   Experientia. Vol. 26, Pg. 283, 1970.
mouse LD50 oral 1050mg/kg (1050mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962.
rabbit LD50 intraperitoneal 300mg/kg (300mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962.