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Substance Name: Flumethasone pivalate [USAN:USP]
RN: 2002-29-1
UNII: 0DV09X6F21
InChIKey: JWRMHDSINXPDHB-OJAGFMMFSA-N

Classification Codes

  • Adrenal Cortex Hormones
  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Glucocorticoids
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists

Molecular Formula

  • C27-H36-F2-O6

Molecular Weight

  • 494.5714
 
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Names and Synonyms

Name of Substance

  • Flumethasone 21-pivalate
  • Flumethasone pivalate
  • Flumethasone pivalate [USAN:USP]

Synonyms

  • 6alpha,9-Difluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-pivalate
  • 6alpha,9alpha-Difluoro-16alpha-methylprednisolone 21-pivalate
  • EINECS 217-901-1
  • Flumetasone pivalate
  • Flumethasone 21-pivalate
  • Flumethasone pivalate
  • Flumethasone-21-pivalate
  • Locacorten
  • Locorten
  • Lorinden
  • NSC 107680
  • UNII-0DV09X6F21

Systematic Names

  • 6alpha,9alpha-Difluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione, 21-pivalate
  • Flumetasone 21-pivalate
  • Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methyl-, (6alpha,11beta,16alpha)-
  • Pregna-1,4-diene-3,20-dione, 6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-, 21-pivalate
  • Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,17,21-trihydroxy-16alpha-methyl-, 21-pivalate (8CI)

Registry Numbers

CAS Registry Number

  • 2002-29-1

FDA UNII

  • 0DV09X6F21

System Generated Number

  • 0002002291

Structure Descriptors

InChI

1S/C27H36F2O6/c1-14-9-16-17-11-19(28)18-10-15(30)7-8-24(18,5)26(17,29)20(31)12-25(16,6)27(14,34)21(32)13-35-22(33)23(2,3)4/h7-8,10,14,16-17,19-20,31,34H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,24+,25+,26+,27+/m1/s1

InChIKey

JWRMHDSINXPDHB-OJAGFMMFSA-N

Smiles

C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C(C)(C)C)O)C)O)F)C)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 705, 1982.
rat LD50 oral > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. 6, Pg. 705, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.86 (none)   EXP
Water Solubility 0.392 mg/L 25 EST
Vapor Pressure 2.75E-14 mm Hg 25 EST
Henry's Law Constant 3.60E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.91E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.