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Substance Name: Angustmycin A
RN: 2004-04-8
InChIKey: UZSSGAOAYPICBZ-SOCHQFKDSA-N

Note

  • From Streptomyces hygroscopicus; inhibits GMP synthesis.

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C11-H13-N5-O4

Molecular Weight

  • 279.2547
 
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Names and Synonyms

Name of Substance

  • Angustmycin A

Synonyms

  • 9-(6-Deoxy-beta-D-erythro-hex-5-enulofuranosyl)adenine
  • 9-(Tetrahydro-3,4-dihydroxy-2-(hydroxymethyl)-5-methylene-2-furyl)adenine
  • 9H-Purin-6-amine, 9-(6-deoxy-beta-D-erythro-hex-5-en-2-ulofuranosyl)-
  • A 14
  • Adenine, 9-(tetrahydro-3,4-dihydroxy-2-(hydroxymethyl)-5-methylene-2-furyl)-
  • AI3-50816
  • Angustmycin A
  • Antibiotic A 14
  • Decoyinin
  • Decoyinine
  • U-7984

Systematic Names

  • 9-(6-Deoxy-beta-D-erythro-hex-5-en-2-ulofuranosyl)-9H-purin-6-amine
  • 9H-Purin-6-amine, 9-(6-deoxy-beta-D-erythro-hex-5-en-2-ulofuranosyl)-
  • Adenine, 9-(6-deoxy-beta-D-erythro-hex-5-enulofuranosyl)-

Registry Numbers

CAS Registry Number

  • 2004-04-8

Other Registry Numbers

  • 1373-27-9
  • 21735-70-6

System Generated Number

  • 0002004048

Structure Descriptors

InChI

1S/C11H13N5O4/c1-5-7(18)8(19)11(2-17,20-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-4,7-8,17-19H,1-2H2,(H2,12,13,14)/t7-,8-,11-/m1/s1

InChIKey

UZSSGAOAYPICBZ-SOCHQFKDSA-N

Smiles

C=C1[C@H]([C@H]([C@](O1)(CO)n2cnc3c2ncnc3N)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 1gm/kg (1000mg/kg)   "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." Vol. 2(6), Pg. -, 1971.
mouse LD50 oral > 2500mg/kg (2500mg/kg)   "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." Vol. 2(6), Pg. -, 1971.
mouse LD50 subcutaneous 2500mg/kg (2500mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 5, Pg. 294, 1981.