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Substance Name: Nimetazepam [INN:JAN]
RN: 2011-67-8
UNII: 4532264KW6
InChIKey: GWUSZQUVEVMBPI-UHFFFAOYSA-N

Note

  • 1-N-methyl derivative of nitrazepam.

Molecular Formula

  • C16-H13-N3-O3

Molecular Weight

  • 295.2967
 

Classification Codes

Classification Codes

  • Anti-Anxiety Agents
  • Anticonvulsants
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • GABA Agents
  • GABA Modulators
  • Hypnotics and Sedatives
  • Mutation Data
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizer
  • Tranquilizing Agents

Superlist Classification Code

  • DEA Schedule IV
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Names and Synonyms

Name of Substance

  • Nimetazepam
  • Nimetazepam [INN:JAN]

Synonyms

  • 1,3-Dihydro-1-methyl-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one
  • 1-Methyl-5-phenyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • 1-Methyl-7-nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • 1-Methylnitrazepam
  • 5-24-04-00346 (Beilstein Handbook Reference)
  • BRN 0759813
  • EINECS 217-931-5
  • Elimin
  • Nimetazepam
  • Nimetazepamum
  • Nimetazepamum [INN-Latin]
  • Ro 5-3453
  • S 1530
  • UNII-4532264KW6

Systematic Names

  • 1,3-Dihydro-1-methyl-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one
  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-1-methyl-7-nitro-5-phenyl-
  • Nimetazepam

Superlist Names

  • DEA No. 2837
  • Erimin
  • Nimetazepam

Registry Numbers

CAS Registry Number

  • 2011-67-8

FDA UNII

  • 4532264KW6

System Generated Number

  • 0002011678

Structure Descriptors

InChI

1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

InChIKey

GWUSZQUVEVMBPI-UHFFFAOYSA-N

Smiles

c12C(=NCC(=O)N(c1ccc(c2)[N+](=O)[O-])C)c1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 510mg/kg (510mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 705, 1973.
mouse LD50 oral 750mg/kg (750mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"
Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 705, 1973.
rat LD50 intraperitoneal 970mg/kg (970mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE WEAKNESS
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.
rat LD50 oral 970mg/kg (970mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.
rat LD50 subcutaneous > 1gm/kg (1000mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 534, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 156.5-7.5 deg C   EXP
log P (octanol-water) 2.16 (none)   EXP
Water Solubility 76.2 mg/L 25 EST
Vapor Pressure 2.11E-09 mm Hg 25 EST
Henry's Law Constant 1.94E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.42E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.