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Substance Name: Calcium Dobesilate [INN]
RN: 20123-80-2
UNII: 5921X1560Q
InChIKey: QGNBTYAQAPLTMX-UHFFFAOYSA-L

Note

  • A drug used to reduce hemorrhage in diabetic retinopathy.

Molecular Formulas

  • C12-H10-Ca-O10-S2
  • C12-H10-O10-S2.Ca
  • C6-H6-O5-S.1/2Ca

Molecular Weight

  • 418.411
 

Classification Codes

  • Coagulants
  • Drug / Therapeutic Agent
  • Hematologic Agents
  • Hemostatics
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Names and Synonyms

Name of Substance

  • Calcium dobesilate
  • Calcium Dobesilate [INN]

MeSH Heading

  • Calcium dobesilate

Synonyms

  • 2,5-Dihydroxybenzenesulfonic acid calcium salt
  • 205 E
  • Calcii dobesilas
  • Calcii dobesilas [INN-Latin]
  • Calcium bis(2,5-dihydroxybenzolsulfonat)
  • Calcium dobesilate
  • Calcium hydrochinonsulfonat
  • Dexium
  • Dobesilate calcium
  • Dobesilate de calcium
  • Dobesilate de calcium [INN-French]
  • Dobesilato calcico
  • Dobesilato calcio
  • Dobesilato calcio [INN-Spanish]
  • Dobesilato di calcio
  • Dobesilato di calcio [DCIT]
  • Doxi-OM
  • Doxium
  • EINECS 243-531-5
  • Hydroquinone calcium sulfonate
  • Nugatex
  • Rasexinium
  • Toraxine
  • UNII-5921X1560Q

Systematic Names

  • Benzenesulfonic acid, 2,5-dihydroxy-, calcium salt
  • Benzenesulfonic acid, 2,5-dihydroxy-, calcium salt (2:1)
  • Calcium 2,5-dihydroxybenzenesulfonate
  • Calcium dobesilate

Registry Numbers

CAS Registry Number

  • 20123-80-2

FDA UNII

  • 5921X1560Q

Related Registry Number

  • 21799-87-1 (mono-potassium salt)

System Generated Number

  • 0020123802

Molecular Formulas

Molecular Formulas

  • C12-H10-Ca-O10-S2
  • C12-H10-O10-S2.Ca
  • C6-H6-O5-S.1/2Ca

Molecular Formula Fragments

  • C12-H10-O10-S2
  • C6-H6-O5-S
  • Ca
  • COMPONENT

Structure Descriptors

InChI

1S/2C6H6O5S.Ca/c2*7-4-1-2-5(8)6(3-4)12(9,10)11;/h2*1-3,7-8H,(H,9,10,11);/q;;+2/p-2

InChIKey

QGNBTYAQAPLTMX-UHFFFAOYSA-L

Smiles

c1(S([O-])(=O)=O)c(ccc(c1)O)O.[O-]S(c1c(ccc(c1)O)O)(=O)=O.[Ca+2]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 4979mg/kg (4979mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: EXCITEMENT
Toksikologicheskii Vestnik. Vol. (1), Pg. 29, 1994.
mouse LD50 intraperitoneal 876mg/kg (876mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toksikologicheskii Vestnik. Vol. (1), Pg. 29, 1994.
mouse LD50 intravenous 775mg/kg (775mg/kg)   Annales Pharmaceutiques Francaises. Vol. 30, Pg. 415, 1972.
mouse LD50 oral 7549mg/kg (7549mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: EXCITEMENT
Toksikologicheskii Vestnik. Vol. (1), Pg. 29, 1994.
mouse LD50 unreported 700mg/kg (700mg/kg)   United States Patent Document. Vol. #3509207,
rat LD50 intravenous 750mg/kg (750mg/kg)   United States Patent Document. Vol. #4513007,
rat LD50 oral 7061mg/kg (7061mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Toksikologicheskii Vestnik. Vol. (1), Pg. 29, 1994.