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Substance Name: Perphenazine dihydrochloride
RN: 2015-28-3
UNII: THW7Y583I9
InChIKey: JGTYANSBOIVAMH-UHFFFAOYSA-N

Note

  • An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H26-Cl-N3-O-S.2Cl-H

Molecular Weight

  • 476.8972
 
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Names and Synonyms

Name of Substance

  • Perphenazine dihydrochloride

Synonyms

  • 4-(3-(2-Chlorophenothiazin-10-yl)propyl)-1-piperazineethanol dihydrochloride
  • EINECS 217-944-6
  • Perphenazine dihydrochloride
  • Perphenazine HCl
  • UNII-THW7Y583I9

Systematic Names

  • 1-Piperazineethanol, 4-(3-(2-chlorophenothiazin-10-yl)propyl)-, dihydrochloride
  • 4-(3-(2-Chloro-10H-phenothiazin-10-yl)propyl)piperazine-1-ethanol dihydrochloride

Registry Numbers

CAS Registry Number

  • 2015-28-3

FDA UNII

  • THW7Y583I9

System Generated Number

  • 0002015283

Molecular Formulas

Molecular Formula

  • C21-H26-Cl-N3-O-S.2Cl-H

Molecular Formula Fragments

  • C21-H26-Cl-N3-O-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H26ClN3OS.2ClH/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26;;/h1-2,4-7,16,26H,3,8-15H2;2*1H

InChIKey

JGTYANSBOIVAMH-UHFFFAOYSA-N

Smiles

Cl.Cl.OCCN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 35mg/kg (35mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 36, 1972.
dog LD50 intravenous 51mg/kg (51mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 36, 1972.
dog LD50 oral > 100mg/kg (100mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 118, Pg. 358, 1959.
mouse LD50 intravenous 19mg/kg (19mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 36, 1972.
mouse LD50 oral 110mg/kg (110mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 118, Pg. 358, 1959.
mouse LD50 subcutaneous 960mg/kg (960mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 36, 1972.
pigeon LD50 intramuscular 250mg/kg (250mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 36, 1972.
pigeon LD50 intravenous 32mg/kg (32mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 36, 1972.
rat LD50 intraperitoneal 124mg/kg (124mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 36, 1972.
rat LD50 intravenous 34mg/kg (34mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 118, Pg. 358, 1959.
rat LD50 oral 318mg/kg (318mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 36, 1972.