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Substance Name: Dilazep dihydrochloride [JAN]
RN: 20153-98-4
UNII: LV48LW10EO
InChIKey: VILIWRRWAWKXRW-UHFFFAOYSA-N

Note

  • Coronary vasodilator with some antiarrhythmic activity.

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C31-H44-N2-O10.2Cl-H

Molecular Weight

  • 677.614
 
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Names and Synonyms

Name of Substance

  • Dilazep dihydrochloride
  • Dilazep dihydrochloride [JAN]

Synonyms

  • 1,4-Bis(3-(3,4,5-trimethoxybenzoyloxy)-propyl)perhydro-1,4-diazepine dihydrochloride
  • AS 05
  • ASTA C
  • ASTA C 4898
  • CCRIS 3782
  • Cormelian
  • Dilazep dihydrochloride
  • Dilazep HCl
  • EINECS 243-548-8
  • K-285
  • Labitan
  • N,N'-(Bis-omega-hydroxypropyl)homopiperazine 3,4,5-trimethoxybenzoate dihydrochloride
  • N,N'-Bis(3-(3,4,5-trimethoxybenzoyloxy)propyl)homopiperazine dihydrochloride
  • Tetrahydro-1H-1,4-diazepine-1,4(5H)-dipropanol bis(3,4,5-trimethoxybenzoate) dihydrochloride
  • UNII-LV48LW10EO

Systematic Names

  • (Tetrahydro-1H-1,4-diazepine-1,4(5H)-diyl)di(propane-1,3-diyl) bis(3,4,5-trimethoxybenzoate) dihydrochloride
  • Benzoic acid, 3,4,5-trimethoxy-, diester with tetrahydro-1H-1,4-diazepine-1,4(5H)dipropanol, dihydrochloride
  • Dilazep dihydrochloride

Registry Numbers

CAS Registry Number

  • 20153-98-4

FDA UNII

  • LV48LW10EO

System Generated Number

  • 0020153984

Molecular Formulas

Molecular Formula

  • C31-H44-N2-O10.2Cl-H

Molecular Formula Fragments

  • C31-H44-N2-O10
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C31H44N2O10.2ClH/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4;;/h18-21H,7-17H2,1-6H3;2*1H

InChIKey

VILIWRRWAWKXRW-UHFFFAOYSA-N

Smiles

c1(cc(c(OC)c(c1)OC)OC)C(OCCC[N@@H+]1CC[N@@H+](CCCOC(c2cc(c(OC)c(c2)OC)OC)=O)CCC1)=O.[ClH-].[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 11200ug/kg (11.2mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 667, 1972.
dog LD50 oral > 316mg/kg (316mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 667, 1972.
mouse LD50 intraperitoneal 161mg/kg (161mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 667, 1972.
mouse LD50 intravenous 16800ug/kg (16.8mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2044, 1974.
mouse LD50 oral 2860mg/kg (2860mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2044, 1974.
mouse LD50 subcutaneous 154mg/kg (154mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 667, 1972.
rat LD50 intraperitoneal 85200ug/kg (85.2mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: TREMOR
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 667, 1972.
rat LD50 intravenous 13700ug/kg (13.7mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2044, 1974.
rat LD50 oral > 2150mg/kg (2150mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 667, 1972.
rat LD50 subcutaneous 369mg/kg (369mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2044, 1974.