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Substance Name: Difenamizole [INN]
RN: 20170-20-1
UNII: 24MR6YLL3W
InChIKey: PCXMKBOWWVXEDT-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H22-N4-O

Molecular Weight

  • 334.4208
 
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Names and Synonyms

Name of Substance

  • Difenamizole
  • Difenamizole [INN]

Synonyms

  • 1,3-Diphenyl-5-(2-dimethylaminopropionamido)pyrazole
  • 2-(Dimethylamino)-N-(1,3-diphenyl-1H-pyrazol-5-yl)propanamide
  • AP-14
  • BRN 0698538
  • Difenamizol
  • Difenamizol [INN-Spanish]
  • Difenamizole
  • Difenamizolum
  • Difenamizolum [INN-Latin]
  • Diphenamizole
  • Pasalin
  • UNII-24MR6YLL3W

Systematic Names

  • 1,3-Diphenyl-5-(2-dimethylaminopropionamido)pyrazole
  • 2-(Dimethylamino)-N-(1,3-diphenylpyrazol-5-yl)propionamide
  • Propanamide, 2-(dimethylamino)-N-(1,3-diphenyl-1H-pyrazol-5-yl)- (9CI)
  • Propionamide, 2-(dimethylamino)-N-(1,3-diphenylpyrazol-5-yl)-

Registry Numbers

CAS Registry Number

  • 20170-20-1

FDA UNII

  • 24MR6YLL3W

Related Registry Number

  • 20170-21-2 (unspecified hydrochloride)

System Generated Number

  • 0020170201

Structure Descriptors

InChI

1S/C20H22N4O/c1-15(23(2)3)20(25)21-19-14-18(16-10-6-4-7-11-16)22-24(19)17-12-8-5-9-13-17/h4-15H,1-3H3,(H,21,25)

InChIKey

PCXMKBOWWVXEDT-UHFFFAOYSA-N

Smiles

CC(C(=O)Nc1cc(nn1c2ccccc2)c3ccccc3)N(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1390mg/kg (1390mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 467, 1973.
mouse LD50 oral 960mg/kg (960mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: TREMOR

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Gifu Daigaku Igakubu Kiyo. Papers of the Gifu University School of Medicine. Vol. 20, Pg. 360, 1972.
mouse LD50 subcutaneous 15200mg/kg (15200mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 467, 1973.
rat LD50 intraperitoneal 1480mg/kg (1480mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 467, 1973.
rat LD50 oral 815mg/kg (815mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: TREMOR

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Gifu Daigaku Igakubu Kiyo. Papers of the Gifu University School of Medicine. Vol. 20, Pg. 360, 1972.
rat LD50 subcutaneous > 12819mg/kg (12819mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 467, 1973.