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Substance Name: Difenamizole hydrochloride
RN: 20170-21-2

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H22-N4-O.x-Cl-H

Molecular Weight

  • 370.882
 
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Names and Synonyms

Results Name

  • Difenamizole hydrochloride

Synonyms

  • 1,3-Diphenyl-5-(2-dimethylaminopropionamide)pyrazole hydrochloride
  • Difenamizole HCl
  • Difenamizole hydrochloride

Systematic Names

  • Propanamide, 2-(dimethylamino)-N-(1,3-diphenyl-1H-pyrazol-5-yl)-, hydrochloride (9CI)
  • Propionamide, 2-(dimethylamino)-N-(1,3-diphenylpyrazol-5-yl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 20170-21-2

Related Registry Number

  • 20170-20-1 (Parent)

System Generated Number

  • 0020170212

Molecular Formulas

Molecular Formula

  • C20-H22-N4-O.x-Cl-H

Molecular Formula Fragments

  • C20-H22-N4-O
  • Cl-H
  • COMPONENT

Structure Descriptors

Smiles

C([C@@H](C)N(C)C)(=O)Nc1cc(nn1c1ccccc1)c1ccccc1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 186mg/kg (186mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: TREMOR
Gifu Daigaku Igakubu Kiyo. Papers of the Gifu University School of Medicine. Vol. 20, Pg. 360, 1972.
mouse LD50 intravenous 92700ug/kg (92.7mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: TREMOR
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 529, 1969.
mouse LD50 oral 560mg/kg (560mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Gifu Daigaku Igakubu Kiyo. Papers of the Gifu University School of Medicine. Vol. 20, Pg. 360, 1972.
mouse LD50 subcutaneous 525mg/kg (525mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Gifu Daigaku Igakubu Kiyo. Papers of the Gifu University School of Medicine. Vol. 20, Pg. 360, 1972.
rabbit LDLo oral 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 679, 1973.
rat LD50 intraperitoneal 396mg/kg (396mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: ANTIPSYCHOTIC

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Gifu Daigaku Igakubu Kiyo. Papers of the Gifu University School of Medicine. Vol. 20, Pg. 360, 1972.
rat LD50 oral 680mg/kg (680mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: TREMOR
Gifu Daigaku Igakubu Kiyo. Papers of the Gifu University School of Medicine. Vol. 20, Pg. 360, 1972.