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Substance Name: Metitepine [INN]
RN: 20229-30-5
UNII: 55D94103HL
InChIKey: RLJFTICUTYVZDG-UHFFFAOYSA-N

Note

  • A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.

Molecular Formula

  • C20-H24-N2-S2

Molecular Weight

  • 356.5556
 

Classification Codes

  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Serotonin Agents
  • Serotonin Antagonists
  • Tranquilizing Agents
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Names and Synonyms

Name of Substance

  • Methiothepin
  • Metitepine
  • Metitepine [INN]

MeSH Heading

  • Methiothepin

Synonyms

  • (+-)-1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine
  • (+-)-10-(4-Methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)thiepin
  • (+-)-8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin
  • 1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine
  • 5-23-02-00468 (Beilstein Handbook Reference)
  • BRN 0626221
  • Dibenzo(b,f)thiepin, 10,11-dihydro-10-(4-methylpiperazinyl)-8-(methylthio)- (+-)
  • Methiothepin
  • Methiothepine
  • Metitepina
  • Metitepina [INN-Spanish]
  • Metitepine
  • Metitepinum
  • Metitepinum [INN-Latin]
  • UNII-55D94103HL

Systematic Names

  • 1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine
  • Piperazine, 1-(10,11-dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methyl-, (+-)-

Registry Numbers

CAS Registry Number

  • 20229-30-5

FDA UNII

  • 55D94103HL

System Generated Number

  • 0020229305

Structure Descriptors

InChI

1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3

InChIKey

RLJFTICUTYVZDG-UHFFFAOYSA-N

Smiles

CN1CCN(CC1)C2Cc3ccccc3Sc4c2cc(cc4)SC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 51mg/kg (51mg/kg)   Drugs of the Future. Vol. 2, Pg. 250, 1977.
mouse LD50 oral 94mg/kg (94mg/kg)   Drugs of the Future. Vol. 2, Pg. 250, 1977.