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Substance Name: Cositecan [USAN:INN]
RN: 203923-89-1
UNII: 24R60NVC41
InChIKey: POADTFBBIXOWFJ-VWLOTQADSA-N

Note

  • A highly lipophilic camptothecin derivative.

Classification Code

  • Antineoplastic Agent

Molecular Formula

  • C25-H28-N2-O4-Si

Molecular Weight

  • 448.5922
 
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Names and Synonyms

Name of Substance

  • Cositecan
  • Cositecan [USAN:INN]

Synonyms

  • (4S)-4-Ethyl-4-hydroxy-11-(2-(trimethylsilyl)ethyl)-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione
  • BNP 1350
  • BNP1350
  • Cositecan
  • DB 172
  • Karenitecin
  • UNII-24R60NVC41

Systematic Name

  • 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-(2-trimethylsilyl)ethyl)-, (4S)-

Registry Numbers

CAS Registry Number

  • 203923-89-1

FDA UNII

  • 24R60NVC41

System Generated Number

  • 0203923891

Structure Descriptors

InChI

1S/C25H28N2O4Si/c1-5-25(30)19-12-21-22-17(13-27(21)23(28)18(19)14-31-24(25)29)15(10-11-32(2,3)4)16-8-6-7-9-20(16)26-22/h6-9,12,30H,5,10-11,13-14H2,1-4H3/t25-/m0/s1

InChIKey

POADTFBBIXOWFJ-VWLOTQADSA-N

Smiles

CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4c(CC[Si](C)(C)C)c5ccccc5nc34)C2=O