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Substance Name: Bornaprine [INN:BAN]
RN: 20448-86-6
UNII: 9M363FGA7J
InChIKey: BDNMABJZSXTKAQ-VCPDFFEISA-N

Note

  • Beneficial effect in Parkinsonism due to inhibition of muscarinic or nicotinic transmission.

Molecular Formula

  • C21-H31-N-O2

Molecular Weight

  • 329.4809
 

Classification Codes

  • Cholinergic Agents
  • Cholinergic Antagonists
  • Muscarinic Antagonists
  • Neurotransmitter Agents
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Names and Synonyms

Name of Substance

  • Bornaprine
  • Bornaprine [INN:BAN]

Synonyms

  • 2-Norbornanecarboxylic acid, 2-phenyl-, 3-(diethylamino)propyl ester
  • 2-Phenyl-2-(gamma-diethylaminocarbopropoxy)-bicyclo(2.2.1)heptane
  • 2-Phenylbicyclo(2.2.1)heptan-2-carbonsaeure-(gamma-diaethylaminopropyl) ester
  • 2-Phenylbicyclo(2.2.1)heptan-2-carbonsaeure-(gamma-diaethylaminopropyl) ester [German]
  • Bornaprine
  • Bornaprino
  • Bornaprino [INN-Spanish]
  • Bornaprinum
  • Bornaprinum [INN-Latin]
  • KR 339
  • KR 339 [German]
  • UNII-9M363FGA7J

Systematic Names

  • 2-Phenylbicyclo(2.2.1)heptane-2-carboxylic acid, 3-(diethylamino)propyl ester
  • 3-(Diethylamino)propyl 2-phenyl-2-norbornanecarboxylate
  • Bicyclo(2.2.1)heptane-2-carboxylic acid, 2-phenyl-, 3-(diethylamino)propyl ester

Registry Numbers

CAS Registry Number

  • 20448-86-6

FDA UNII

  • 9M363FGA7J

Related Registry Number

  • 26908-91-8 (hydrochloride)

System Generated Number

  • 0020448866

Structure Descriptors

InChI

1S/C21H31NO2/c1-3-22(4-2)13-8-14-24-20(23)21(18-9-6-5-7-10-18)16-17-11-12-19(21)15-17/h5-7,9-10,17,19H,3-4,8,11-16H2,1-2H3/t17-,19+,21?/m1/s1

InChIKey

BDNMABJZSXTKAQ-VCPDFFEISA-N

Smiles

CCN(CC)CCCOC(=O)C1(C[C@@H]2CC[C@H]1C2)c3ccccc3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 26mg/kg (26mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 128, Pg. 204, 1960.
mouse LD50 subcutaneous 112mg/kg (112mg/kg) BEHAVIORAL: ATAXIA

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 128, Pg. 204, 1960.