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Substance Name: Clothiapine [USAN]
RN: 2058-52-8
UNII: Z05HCY0X1T
InChIKey: KAAZGXDPUNNEFN-UHFFFAOYSA-N
Note
- Antipsychotic similar to clozapine.
Molecular Formula
- C18-H18-Cl-N3-S
Molecular Weight
- 343.8802
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antipsychotic
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Psychotropic Drugs
- Reproductive Effect
- Tranquilizing Agents
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Links to Resources
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Names and Synonyms
Name of Substance
- Clothiapine
- Clothiapine [USAN]
- Clotiapine [INN]
Synonyms
- 2-Chloro-11-(4-methyl-1-piperazinyl)dibenzo(b,f)(1,4)thiazepine
- 2-Chloro-11-(4-methylpiperazino)dibenzo(b,f)(1,4)thiazepine
- BRN 0568276
- Clothiapine
- Clotiapina
- Clotiapina [INN-Spanish]
- Clotiapine
- Clotiapinum
- Clotiapinum [INN-Latin]
- Dibenzo(b,f)(1,4)thiazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-
- Dibenzothiazepine
- EINECS 218-162-8
- Entumin
- Etumine
- HF 2159
- HF-2159
- LW 2159
- S-805C
- UNII-Z05HCY0X1T
- W 130
Systematic Names
- Clotiapine
- Dibenzo(b,f)(1,4)thiazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-
Registry Numbers
CAS Registry Number
- 2058-52-8
FDA UNII
- Z05HCY0X1T
System Generated Number
- 0002058528
Structure Descriptors
InChI
InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3InChIKey
KAAZGXDPUNNEFN-UHFFFAOYSA-NSmiles
CN1CCN(CC1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | oral | 150mg/kg (150mg/kg) | Toxicology and Applied Pharmacology. Vol. 14, Pg. 657, 1969. | |
| mouse | LD50 | intramuscular | 160mg/kg (160mg/kg) | Drugs in Japan Vol. 6, Pg. 234, 1982. | |
| mouse | LD50 | intravenous | 46mg/kg (46mg/kg) | Drugs in Japan Vol. 6, Pg. 234, 1982. | |
| mouse | LD50 | oral | 270mg/kg (270mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 841, 1965. | |
| mouse | LD50 | subcutaneous | 348mg/kg (348mg/kg) | Drugs in Japan Vol. 6, Pg. 234, 1982. | |
| rat | LD50 | intramuscular | > 300mg/kg (300mg/kg) | Drugs in Japan Vol. 6, Pg. 233, 1982. | |
| rat | LD50 | intravenous | 47mg/kg (47mg/kg) | Drugs in Japan Vol. -, Pg. 404, 1995. | |
| rat | LD50 | oral | 280mg/kg (280mg/kg) | Drugs in Japan Vol. 6, Pg. 234, 1982. | |
| rat | LD50 | subcutaneous | > 500mg/kg (500mg/kg) | Drugs in Japan Vol. 6, Pg. 233, 1982. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 119 | deg C | EXP | |
| log P (octanol-water) | 3.840 | (none) | EST | |
| Atmospheric OH Rate Constant | 1.94E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.