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Substance Name: Trifluperidol hydrochloride
RN: 2062-77-3
UNII: UIC8RB6P81
InChIKey: VYGQXRZAHIZHQV-UHFFFAOYSA-N

Note

  • A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in the treatment of PSYCHOSES including MANIA and SCHIZOPHRENIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p621)

Molecular Formula

  • C22-H23-F4-N-O2.Cl-H

Molecular Weight

  • 445.8816
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Trifluperidol hydrochloride

Synonyms

  • 4'-Fluoro-4-(4-hydroxy-4-trifluoromethylphenylpiperidino)butyrophenone hydrochloride
  • EINECS 218-170-1
  • Flumoperone hydrochloride
  • NSC 169875
  • Psycoperidol hydrochloride
  • R 2498
  • Trifluperidol
  • Trifluperidol chlorhydrate
  • Trifluperidol HCl
  • Trifluperidol hydrochloride
  • Triperidol hydrochloride
  • Trisedil hydrochloride
  • Trisedyl hydrochloride
  • UNII-UIC8RB6P81

Systematic Names

  • 1-Butanone, 1-(4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)-1-piperidinyl)-, hydrochloride (9CI)
  • Butyrophenone, 4'-fluoro-4-(4-hydroxy-4-(alpha,alpha,alpha-trifluoro-m-tolyl)piperidino)-, hydrochloride
  • Butyrophenone, 4'-fluoro-4-(4-hydroxy-4-(alpha,alpha,alpha-trifluoro-m-tolyl)piperidino)-, hydrochloride (VAN) (8CI)
  • Trifluperidol hydrochloride

Registry Numbers

CAS Registry Number

  • 2062-77-3

FDA UNII

  • UIC8RB6P81

System Generated Number

  • 0002062773

Molecular Formulas

Molecular Formula

  • C22-H23-F4-N-O2.Cl-H

Molecular Formula Fragments

  • C22-H23-F4-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C22H23F4NO2.ClH/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26;/h1,3-4,6-9,15,29H,2,5,10-14H2;1H

InChIKey

VYGQXRZAHIZHQV-UHFFFAOYSA-N

Smiles

c1cc(cc(c1)C(F)(F)F)C2(CC[NH+](CC2)CCCC(=O)c3ccc(cc3)F)O.[Cl-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 64mg/kg (64mg/kg)   Therapie. Vol. 17, Pg. 1053, 1962.
mouse LD50 intraperitoneal 36mg/kg (36mg/kg)   Therapie. Vol. 17, Pg. 1053, 1962.
mouse LD50 intravenous 17400ug/kg (17.4mg/kg)   Therapie. Vol. 17, Pg. 1053, 1962.
mouse LD50 oral 99mg/kg (99mg/kg)   Therapie. Vol. 17, Pg. 1053, 1962.
mouse LD50 subcutaneous 80mg/kg (80mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 194, 1972.
rat LD50 intravenous 14mg/kg (14mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 194, 1972.
rat LDLo intramuscular 35mg/kg (35mg/kg)   Therapie. Vol. 17, Pg. 1053, 1962.
rat LDLo oral 75mg/kg (75mg/kg)   Therapie. Vol. 17, Pg. 1053, 1962.