|
|
Substance Name: Pimozide [USAN:USP:INN:BAN:JAN]
RN: 2062-78-4
UNII: 1HIZ4DL86F
InChIKey: YVUQSNJEYSNKRX-UHFFFAOYSA-N
Note
- A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403).
Molecular Formula
- C28-H29-F2-N3-O
Molecular Weight
- 461.5531
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Dyskinesia Agents
- Antipsychotic
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Drug / Therapeutic Agent
- Human Data
- Neurotransmitter Agents
- Psychotropic Drugs
- Reproductive Effect
- Tranquilizing Agents
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Pimozide
- Pimozide [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Pimozide
Synonyms
- 1-(1-(4,4-Bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinone
- 1-(4,4-Bis(p-fluorophenyl)butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine
- 2H-Benzimidazol-2-one, 1-(1-(4,4-bis(4-fluorophenyl)butyl)-4-piperidinyl)-1,3-dihydro-
- 5-24-02-00367 (Beilstein Handbook Reference)
- BRN 0729089
- CCRIS 9172
- EINECS 218-171-7
- McN-JR-6238
- NSC 170984
- Opiran
- Orap
- Pimozide
- Pimozidum
- Pimozidum [INN-Latin]
- Primozida
- Primozida [INN-Spanish]
- R 6238
- UNII-1HIZ4DL86F
Systematic Names
- 2H-Benzimidazol-2-one, 1-(1-(4,4-bis(4-fluorophenyl)butyl)-4-piperidinyl)-1,3-dihydro-
- Pimozide
Superlist Name
- Pimozide
Registry Numbers
CAS Registry Number
- 2062-78-4
FDA UNII
- 1HIZ4DL86F
System Generated Number
- 0002062784
Structure Descriptors
InChI
InChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)InChIKey
YVUQSNJEYSNKRX-UHFFFAOYSA-NSmiles
Fc1ccc(cc1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | 32mg/kg (32mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974. | |
dog | LD50 | oral | 40mg/kg (40mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 261, 1968. |
guinea pig | LD50 | oral | 189mg/kg (189mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR | Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 261, 1968. |
man | TDLo | oral | 7714ug/kg/15W (7.714mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FLUID INTAKE KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Journal of Clinical Pyschopharmacology. Vol. 12, Pg. 140, 1992. |
mouse | LD50 | intraperitoneal | 1070mg/kg (1070mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974. | |
mouse | LD50 | intravenous | 14mg/kg (14mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 288, 1972. | |
mouse | LD50 | oral | 228mg/kg (228mg/kg) | BEHAVIORAL: ATAXIA | Collection of Czechoslovak Chemical Communications. Vol. 42, Pg. 1179, 1977. |
mouse | LD50 | subcutaneous | > 16gm/kg (16000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 629, 1972. | |
mouse | LD50 | subcutaneous | > 16gm/kg (16000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS | Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 629, 1972. |
rabbit | LD50 | intravenous | 22mg/kg (22mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974. | |
rabbit | LD50 | oral | 40mg/kg (40mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974. | |
rat | LD50 | intraperitoneal | 350mg/kg (350mg/kg) | Drugs in Japan Vol. 6, Pg. 639, 1982. | |
rat | LD50 | intravenous | 90mg/kg (90mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974. | |
rat | LD50 | oral | 1100mg/kg (1100mg/kg) | Drugs in Japan Vol. 6, Pg. 639, 1982. | |
rat | LD50 | subcutaneous | > 11gm/kg (11000mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 629, 1972. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 214-218 | deg C | EXP | |
pKa Dissociation Constant | 8.63 | (none) | EXP | |
log P (octanol-water) | 6.3 | (none) | EXP | |
Water Solubility | 10 | mg/L | 25 | EXP |
Vapor Pressure | 6.25E-13 | mm Hg | 25 | EST |
Henry's Law Constant | 1.10E-13 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.46E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.