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Substance Name: Darunavir [USAN:INN:BAN]
RN: 206361-99-1
UNII: YO603Y8113
InChIKey: CJBJHOAVZSMMDJ-HEXNFIEUSA-N

Notes

  • An HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other ANTI-HIV AGENTS.
  • Prezista=TMC114=darunavir ethanolate 300-mg.

Molecular Formula

  • C27-H37-N3-O7-S

Molecular Weight

  • 547.6693
 

Classification Codes

  • Anti-HIV Agents
  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antiviral
  • Antiviral Agents
  • Enzyme Inhibitors
  • HIV Protease Inhibitors
  • Protease Inhibitors
  • Treatment of HIV Infection

Names and Synonyms

Name of Substance

  • Darunavir
  • Darunavir [USAN:INN:BAN]

MeSH Heading

  • Darunavir

Synonyms

  • ((1S,2R)-3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-carbamic acid (3R,3aS,6aR)-hexahydrofurano(2,3-b)furan-3-yl ester
  • (3R,3aS,6aR)-Hexahydrofuro(2,3-b)furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N(sup 1)-isobutylsulfanilamido)propyl)carbamate
  • Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-, (3R,3aS,6aR)-hexahydrofurano(2,3-b)furan-3-yl ester
  • Darunavir
  • Darunavirum
  • Darunavirum [INN-Latin]
  • HSDB 7788
  • Prezista
  • TMC 114
  • TMC 41629
  • TMC114
  • TMC41629
  • UIC 94017
  • UIC-94017
  • UNII-YO603Y8113

Systematic Names

  • (3R,3aS,6aR)-Hexahydrofuro(2,3-b)furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N1-isobutylsulfanilamido)propyl)carbamate
  • N-((1S,2R)-3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-benzylpropyl)((1S,2R,5R)-4,6-dioxabicyclo(3.3.0)oct-2-yloxy)carboxamide

Registry Numbers

CAS Registry Number

  • 206361-99-1

FDA UNII

  • YO603Y8113

Other Registry Numbers

  • 1097732-88-1
  • 618109-00-5

System Generated Number

  • 0206361991

Structure Descriptors

InChI

1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1

InChIKey

CJBJHOAVZSMMDJ-HEXNFIEUSA-N

Smiles

CC(C)CN(C[C@H]([C@H](Cc1ccccc1)NC(=O)O[C@H]2CO[C@@H]3[C@H]2CCO3)O)S(=O)(=O)c4ccc(cc4)N