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Substance Name: Vincristine sulfate [USAN:USP:JAN]
RN: 2068-78-2
UNII: T5IRO3534A
InChIKey: AQTQHPDCURKLKT-PNYVAJAMSA-N

Note

  • Antitumor alkaloid isolated from Vinca Rosea. (Merck, 11th ed.)

Molecular Formula

  • C46-H56-N4-O10.H2-O4-S

Molecular Weight

  • 923.0442
 

Classification Codes

Classification Codes

  • Antineoplastic
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3

Names and Synonyms

Name of Substance

  • Vincristine sulfate [USAN:USP:JAN]

Synonyms

  • 37231
  • AI3-52944
  • Alkaloid extracted from Vinca rosea Linn
  • CCRIS 2583
  • EINECS 218-190-0
  • Kyocristine
  • Leurocristine sulfate (1:1) (salt)
  • Lilly 37231
  • Marqibo
  • Marqibo Kit
  • NSC 67574
  • Oncovin
  • Onkovin
  • UNII-T5IRO3534A
  • VCR sulfate
  • Vincaleukoblastine, 22-oxo-, sulfate (1:1) (salt)
  • Vincasar PFS
  • Vincrex
  • Vincristine sulfate
  • Vincristine Sulfate Liposomes Injection
  • Vincristine sulfate PFS
  • Vincristine sulphate
  • Vincristinsulfat
  • Vincristinsulfat [German]
  • Vincrisul

Systematic Names

  • Leurocristine, sulfate (1:1) (salt) (8CI)
  • Vincaleukoblastine, 22-oxo-, sulfate (1:1) (salt)
  • Vincristine sulfate
  • Vincristine sulphate

Superlist Names

  • Vincristine sulfate
  • Vincristine sulphate

Registry Numbers

CAS Registry Number

  • 2068-78-2

FDA UNII

  • T5IRO3534A

System Generated Number

  • 0002068782

Molecular Formulas

Molecular Formula

  • C46-H56-N4-O10.H2-O4-S

Molecular Formula Fragments

  • C46-H56-N4-O10
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1

InChIKey

AQTQHPDCURKLKT-PNYVAJAMSA-N

Smiles

CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)[C@H]7[C@](O)([C@H](OC(=O)C)[C@]8(CC)C=CCN9CC[C@]67[C@H]89)C(=O)OC)C1.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LDLo intraperitoneal 4mg/kg (4mg/kg)   Cancer Chemotherapy and Pharmacology. Vol. 20, Pg. 21, 1987.
monkey LD oral > 4mg/kg (4mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 157, Pg. 299, 1965.
monkey LDLo intravenous 4mg/kg (4mg/kg) BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE

BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 157, Pg. 299, 1965.
mouse LD50 intraperitoneal 3mg/kg (3mg/kg)   Drugs in Japan Vol. 6, Pg. 648, 1982.
mouse LD50 intravenous 1700ug/kg (1.7mg/kg)   Cancer Research. Vol. 39, Pg. 3575, 1979.
rat LD50 intraperitoneal 1900ug/kg (1.9mg/kg)   Drugs in Japan Vol. 6, Pg. 648, 1982.
rat LD50 intravenous 1010ug/kg (1.01mg/kg) BLOOD: NORMOCYTIC ANEMIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.82 (none)   EXP
Atmospheric OH Rate Constant 6.57E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.