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Substance Name: LY-3164530
RN: 2069210-01-9
UNII: K85WE44TZ7

Note

  • NCI: anti-Met/EGFR monoclonal antibody LY3164530. A monoclonal antibody (MoAb) against human epidermal growth factor receptor (EGFR) and human hepatocyte growth factor receptor (HGFR or c-Met), with potential antineoplastic activity. Upon administration, anti-Met/EGFR MoAb LY3164530 targets and prevents the activation of EGFR and c-Met. This leads to a downstream inhibition of EGFR/c-Met-mediated signal transduction pathways, and prevents cellular proliferation in tumor cells overexpressing EGFR and c-Met. EGFR, a member of the epidermal growth factor family of extracellular protein ligands, may be overexpressed on the cell surface of various solid tumor cell types. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis. (NCI Thesaurus)
 
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Names and Synonyms

Name of Substance

  • LY-3164530

Synonyms

  • anti-Met/EGFR monoclonal antibody LY3164530
  • LY 3164530
  • LY3164530
  • UNII-K85WE44TZ7
  • UNII-K85WE44TZ7

Registry Numbers

CAS Registry Number

  • 2069210-01-9

FDA UNII

  • K85WE44TZ7

System Generated Number

  • 2069210019