Skip Navigation
ChemIDplus Lite•Browse•Advanced

Substance Name: Binetrakin [USAN:INN]
RN: 207137-56-2
UNII: 751635Z921

Notes

  • A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
  • [FUNCTION] IL-4 PARTICIPATES IN AT LEAST SEVERAL B-CELL ACTIVATION PROCESSES AS WELL AS OF OTHER CELL TYPES. IT IS A COSTIMULATOR OF DNA-SYNTHESIS. IT INDUCES THE EXPRESSION OF CLASS II MHC MOLECULES ON RESTING B-CELLS. IT ENHANCES BOTH SECRETION AND CELL SURFACE EXPRESSION OF IGE AND IGG1. IT ALSO REGULATES THE EXPRESSION OF THE LOW AFFINITY FC RECEPTOR FOR IGE (CD23) ON BOTH LYMPHOCYTES AND MONOCYTES. [SUBCELLULAR LOCATION] SECRETED. [ALTERNATIVE PRODUCTS] 2 ISOFORMS; A LONG FORM (SHOWN HERE) AND A SHORT FORM; ARE PRODUCED BY ALTERNATIVE SPLICING. [SIMILARITY] BELONGS TO THE IL-4 / IL-13 FAMILY.

Molecular Formula

  • Unspecified

Molecular Weight

  • 15088.3335
 

Classification Codes

  • Adjuvants, Immunologic
  • Antineoplastic Agents
  • Antirheumatic Agents
  • Immunologic Factors
  • Immunomodulatory Activities on B Cells, Macrophages, Eosinophils and Other Hematopoietic Cells
  • Treatment of Gastrointestinal Carcinoma, Rheumatoid Arthritis and Dendritic Cell Activation (Immunomodulatory Activities on B Cells, Macrophages, Eosinophils and Other Hematopoietic Cells)

Names and Synonyms

Name of Substance

  • Binetrakin [USAN:INN]

MeSH Heading

  • Interleukin-4

Synonyms

  • B-cell stimulatory factor 1
  • BCGF-1
  • Binetrakin
  • BSF-1
  • IL-4
  • Interleukin 4 (human)
  • Interleukin 4 (human). Molecular weight is approximately 14,900 daltons
  • Interleukin-4
  • Lymphocyte stimulatory factor 1
  • Mast Cell Growth Factor-2
  • MCGF-2
  • Recombinant interleukin-4
  • SCH 39400
  • UNII-751635Z921

Systematic Name

  • Interleukin 4 (human) 129

Registry Numbers

CAS Registry Number

  • 207137-56-2

FDA UNII

  • 751635Z921

System Generated Number

  • 0207137562

Structure Descriptors

Smiles

CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]5CSSC[C@@H]6NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc7ccc(O)cc7)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc8ccccc8)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H]9CCCN9C(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc%10ccccc%10)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc%11ccccc%11)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC6=O)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc%12ccccc%12)C(=O)N[C@@H](Cc%13ccc(O)cc%13)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc%14cnc[nH]%14)C(=O)N[C@@H](Cc%15cnc[nH]%15)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N5)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc%16c[nH]c%17ccccc%16%17)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc%18ccccc%18)NC(=O)[C@H](CCCNC(=N)N)NC1=O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc%19cnc[nH]%19)NC(=O)[C@@H](N)CCSC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O