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Substance Name: Binetrakin [USAN:INN]
RN: 207137-56-2
UNII: 751635Z921
Notes
- A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
- [FUNCTION] IL-4 PARTICIPATES IN AT LEAST SEVERAL B-CELL ACTIVATION PROCESSES AS WELL AS OF OTHER CELL TYPES. IT IS A COSTIMULATOR OF DNA-SYNTHESIS. IT INDUCES THE EXPRESSION OF CLASS II MHC MOLECULES ON RESTING B-CELLS. IT ENHANCES BOTH SECRETION AND CELL SURFACE EXPRESSION OF IGE AND IGG1. IT ALSO REGULATES THE EXPRESSION OF THE LOW AFFINITY FC RECEPTOR FOR IGE (CD23) ON BOTH LYMPHOCYTES AND MONOCYTES. [SUBCELLULAR LOCATION] SECRETED. [ALTERNATIVE PRODUCTS] 2 ISOFORMS; A LONG FORM (SHOWN HERE) AND A SHORT FORM; ARE PRODUCED BY ALTERNATIVE SPLICING. [SIMILARITY] BELONGS TO THE IL-4 / IL-13 FAMILY.
Molecular Formula
- Unspecified
Molecular Weight
- 15088.3335
Classification Codes
- Adjuvants, Immunologic
- Antineoplastic Agents
- Antirheumatic Agents
- Immunologic Factors
- Immunomodulatory Activities on B Cells, Macrophages, Eosinophils and Other Hematopoietic Cells
- Treatment of Gastrointestinal Carcinoma, Rheumatoid Arthritis and Dendritic Cell Activation (Immunomodulatory Activities on B Cells, Macrophages, Eosinophils and Other Hematopoietic Cells)
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Names and Synonyms
Name of Substance
- Binetrakin [USAN:INN]
MeSH Heading
- Interleukin-4
Synonyms
- B-cell stimulatory factor 1
- BCGF-1
- Binetrakin
- BSF-1
- IL-4
- Interleukin 4 (human)
- Interleukin 4 (human). Molecular weight is approximately 14,900 daltons
- Interleukin-4
- Lymphocyte stimulatory factor 1
- Mast Cell Growth Factor-2
- MCGF-2
- Recombinant interleukin-4
- SCH 39400
- UNII-751635Z921
Systematic Name
- Interleukin 4 (human) 129
Registry Numbers
CAS Registry Number
- 207137-56-2
FDA UNII
- 751635Z921
System Generated Number
- 0207137562