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Substance Name: Binetrakin [USAN:INN]
RN: 207137-56-2
UNII: 751635Z921

Notes

  • A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
  • [FUNCTION] IL-4 PARTICIPATES IN AT LEAST SEVERAL B-CELL ACTIVATION PROCESSES AS WELL AS OF OTHER CELL TYPES. IT IS A COSTIMULATOR OF DNA-SYNTHESIS. IT INDUCES THE EXPRESSION OF CLASS II MHC MOLECULES ON RESTING B-CELLS. IT ENHANCES BOTH SECRETION AND CELL SURFACE EXPRESSION OF IGE AND IGG1. IT ALSO REGULATES THE EXPRESSION OF THE LOW AFFINITY FC RECEPTOR FOR IGE (CD23) ON BOTH LYMPHOCYTES AND MONOCYTES. [SUBCELLULAR LOCATION] SECRETED. [ALTERNATIVE PRODUCTS] 2 ISOFORMS; A LONG FORM (SHOWN HERE) AND A SHORT FORM; ARE PRODUCED BY ALTERNATIVE SPLICING. [SIMILARITY] BELONGS TO THE IL-4 / IL-13 FAMILY.

Molecular Formula

  • Unspecified

Molecular Weight

  • 15088.3335
 

Classification Codes

  • Adjuvants, Immunologic
  • Antineoplastic Agents
  • Antirheumatic Agents
  • Immunologic Factors
  • Immunomodulatory Activities on B Cells, Macrophages, Eosinophils and Other Hematopoietic Cells
  • Treatment of Gastrointestinal Carcinoma, Rheumatoid Arthritis and Dendritic Cell Activation (Immunomodulatory Activities on B Cells, Macrophages, Eosinophils and Other Hematopoietic Cells)

Names and Synonyms

Name of Substance

  • Binetrakin [USAN:INN]

MeSH Heading

  • Interleukin-4

Synonyms

  • B-cell stimulatory factor 1
  • BCGF-1
  • Binetrakin
  • BSF-1
  • IL-4
  • Interleukin 4 (human)
  • Interleukin 4 (human). Molecular weight is approximately 14,900 daltons
  • Interleukin-4
  • Lymphocyte stimulatory factor 1
  • Mast Cell Growth Factor-2
  • MCGF-2
  • Recombinant interleukin-4
  • SCH 39400
  • UNII-751635Z921

Systematic Name

  • Interleukin 4 (human) 129

Registry Numbers

CAS Registry Number

  • 207137-56-2

FDA UNII

  • 751635Z921

System Generated Number

  • 0207137562