Substance Name: Binetrakin [USAN:INN]
RN: 207137-56-2
UNII: 751635Z921

A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.

[FUNCTION] IL-4 PARTICIPATES IN AT LEAST SEVERAL B-CELL ACTIVATION PROCESSES AS WELL AS OF OTHER CELL TYPES. IT IS A COSTIMULATOR OF DNA-SYNTHESIS. IT INDUCES THE EXPRESSION OF CLASS II MHC MOLECULES ON RESTING B-CELLS. IT ENHANCES BOTH SECRETION AND CELL SURFACE EXPRESSION OF IGE AND IGG1. IT ALSO REGULATES THE EXPRESSION OF THE LOW AFFINITY FC RECEPTOR FOR IGE (CD23) ON BOTH LYMPHOCYTES AND MONOCYTES. [SUBCELLULAR LOCATION] SECRETED. [ALTERNATIVE PRODUCTS] 2 ISOFORMS; A LONG FORM (SHOWN HERE) AND A SHORT FORM; ARE PRODUCED BY ALTERNATIVE SPLICING. [SIMILARITY] BELONGS TO THE IL-4 / IL-13 FAMILY.

Unspecified